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Am J Physiol Heart Circ Physiol 282: H380-H388, 2002;
0363-6135/02 $5.00
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Vol. 282, Issue 1, H380-H388, January 2002

Effects of age, gender, and blood pressure on myogenic responses of mesenteric arteries from C57BL/6 mice

Robert Gros1,2, Ryan Van Wert1,2, Xiaomang You1,2, Eric Thorin3, and Mansoor Husain1,2

1 Heart and Stroke Richard Lewar Center of Excellence, University of Toronto, Toronto, Ontario; 2 Division of Cellular & Molecular Biology, Toronto General Hospital Research Institute, Toronto, Ontario M5G 2C4; and 3 The Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada

The myogenic response (MR) may represent an important physiological parameter underlying arterial blood pressure (BP). We studied the effects of age, gender, and BP on the MR of mesenteric arteries from 8- to 52-wk-old mice. Increasing age and BP are associated with an increase in the perfusion pressure at which tone develops (myogenic set point). An inverse correlation exists between age and extent (magnitude) of the MR in male (r2 = 0.93, P = 0.0087) and female mice (r2 = 0.90, P = 0.013) as well as between BP and extent of the MR in male (r2 = 0.96, P = 0.0036) and female (r2 = 0.90, P = 0.014) mice. In contrast, the strength of the MR (slope of active diameter-pressure relationship) and phenylephrine-mediated constriction did not differ among these groups. Although gender had no effect on MR at any perfusion pressure or age, only male mice showed significant salt-induced hypertension and an associated increase in the set point and reduction in the extent of the MR. The set point and extent of the MR is linked to the in vivo pressure during development and experimental hypertension.

salt-induced hypertension


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