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Departments of 1 General Medicine and 3 Cardiology, Christchurch Hospital; 2 Department of Medicine, Christchurch School of Medicine, Christchurch, New Zealand; and 4 Howard Florey Institute, Melbourne, Australia
Cardiac sympathetic nerve activity (CSNA) is of major
importance in the etiology of heart disease but is impossible to
measure directly in humans. Ovine and human cardiovascular systems are similar; therefore, we have developed a method for the daily recording of CSNA in conscious sheep. After thoracotomy, electrodes were glued
into the left thoracic cardiac nerve and CSNA, blood pressure (BP), and
heart rate were recorded daily. Satisfactory recordings 
7 days of
CSNA were obtained in 11 of 28 sheep (40%), mean recording time 10.6 days, range 7-47. During the first week, CSNA decreased gradually from
78 ± 8 at baseline to 60 ± 7 bursts/min on day 5 (P = 0.02) or from 76 ± 9 to 57 ± 7 bursts/100 beats on day 7 (P = 0.04).
Similarly, BP decreased from 103 ± 4 to 94 ± 4 mmHg (P = 0.03). Low-frequency heart rate variability
decreased from 0.12 ± 0.02 to 0.06 ± 0.02 ms2
on day 6 (P = 0.004) but was not correlated
to CSNA. In conclusion, CSNA that can be continually recorded in
conscious sheep decreases during the first week postsurgery and,
thereafter, stabilizes. This model should provide valuable insights in
future investigations of cardiac disease.
sympathetic nervous system; ovine model; baroreflex
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