AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 282: H516-H530, 2002. First published October 4, 2001; doi:10.1152/ajpheart.00612.2001
0363-6135/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/2/H516    most recent
00612.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (93)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fox, J. J.
Right arrow Articles by Gilmour, R. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fox, J. J.
Right arrow Articles by Gilmour, R. F., Jr
Vol. 282, Issue 2, H516-H530, February 2002

Ionic mechanism of electrical alternans

Jeffrey J. Fox1,2, Jennifer L. McHarg1, and Robert F. Gilmour Jr1

1 Department of Biomedical Sciences and 2 Department of Physics, Cornell University, Ithaca, New York 14853-6401

Although alternans of action potential duration (APD) is a robust feature of the rapidly paced canine ventricle, currently available ionic models of cardiac myocytes do not recreate this phenomenon. To address this problem, we developed a new ionic model using formulations of currents based on previous models and recent experimental data. Compared with existing models, the inward rectifier K+ current (IK1) was decreased at depolarized potentials, the maximum conductance and rectification of the rapid component of the delayed rectifier K+ current (IKr) were increased, and IKr activation kinetics were slowed. The slow component of the delayed rectifier K+ current (IKs) was increased in magnitude and activation shifted to less positive voltages, and the L-type Ca2+ current (ICa) was modified to produce a smaller, more rapidly inactivating current. Finally, a simplified form of intracellular calcium dynamics was adopted. In this model, APD alternans occurred at cycle lengths = 150-210 ms, with a maximum alternans amplitude of 39 ms. APD alternans was suppressed by decreasing ICa magnitude or calcium-induced inactivation and by increasing the magnitude of IK1, IKr, or IKs. These results establish an ionic basis for APD alternans, which should facilitate the development of pharmacological approaches to eliminating alternans.

action potential duration restitution; calcium current; potassium currents


This article has been cited by other articles:


Home page
 Biophys. JHome page
J. G. Restrepo, J. N. Weiss, and A. Karma
Calsequestrin-Mediated Mechanism for Cellular Calcium Transient Alternans
Biophys. J., October 15, 2008; 95(8): 3767 - 3789.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. Stoll, M. Quentin, A. Molojavyi, V. Thamer, and U. K.M. Decking
Spatial heterogeneity of myocardial perfusion predicts local potassium channel expression and action potential duration
Cardiovasc Res, February 1, 2008; 77(3): 489 - 496.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. M. Cordeiro, J. E. Malone, J. M. Di Diego, F. S. Scornik, G. L. Aistrup, C. Antzelevitch, and J. A. Wasserstrom
Cellular and subcellular alternans in the canine left ventricle
Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3506 - H3516.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Z. I. Zhu and C. E. Clancy
L-type Ca2+ channel mutations and T-wave alternans: a model study
Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3480 - H3489.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. N. Jordan and D. J. Christini
Characterizing the contribution of voltage- and calcium-dependent coupling to action potential stability: implications for repolarization alternans
Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2109 - H2118.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
V. Gudzenko, Y. Shiferaw, N. Savalli, R. Vyas, J. N. Weiss, and R. Olcese
Influence of channel subunit composition on L-type Ca2+ current kinetics and cardiac wave stability
Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1805 - H1815.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. M. Livshitz and Y. Rudy
Regulation of Ca2+ and electrical alternans in cardiac myocytes: role of CAMKII and repolarizing currents
Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2854 - H2866.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
D. Sato, Y. Shiferaw, Z. Qu, A. Garfinkel, J. N. Weiss, and A. Karma
Inferring the Cellular Origin of Voltage and Calcium Alternans from the Spatial Scales of Phase Reversal during Discordant Alternans
Biophys. J., February 15, 2007; 92(4): L33 - L35.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
T. Krogh-Madsen and D. J. Christini
Action Potential Duration Dispersion and Alternans in Simulated Heterogeneous Cardiac Tissue with a Structural Barrier
Biophys. J., February 15, 2007; 92(4): 1138 - 1149.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
H. Hayashi, Y. Shiferaw, D. Sato, M. Nihei, S.-F. Lin, P.-S. Chen, A. Garfinkel, J. N. Weiss, and Z. Qu
Dynamic Origin of Spatially Discordant Alternans in Cardiac Tissue
Biophys. J., January 15, 2007; 92(2): 448 - 460.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. M. Cherry and F. H. Fenton
A tale of two dogs: analyzing two models of canine ventricular electrophysiology
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H43 - H55.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. F. Noujaim, S. V. Pandit, O. Berenfeld, K. Vikstrom, M. Cerrone, S. Mironov, M. Zugermayr, A. N. Lopatin, and J. Jalife
Up-regulation of the inward rectifier K+ current (IK1) in the mouse heart accelerates and stabilizes rotors
J. Physiol., January 1, 2007; 578(1): 315 - 326.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Baher, Z. Qu, A. Hayatdavoudi, S. T. Lamp, M.-J. Yang, F. Xie, S. Turner, A. Garfinkel, and J. N. Weiss
Short-term cardiac memory and mother rotor fibrillation
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H180 - H189.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
E. G. Tolkacheva, J. M. B. Anumonwo, and J. Jalife
Action Potential Duration Restitution Portraits of Mammalian Ventricular Myocytes: Role of Calcium Current
Biophys. J., October 1, 2006; 91(7): 2735 - 2745.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
E. Picht, J. DeSantiago, L. A. Blatter, and D. M. Bers
Cardiac Alternans Do Not Rely on Diastolic Sarcoplasmic Reticulum Calcium Content Fluctuations
Circ. Res., September 29, 2006; 99(7): 740 - 748.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
G. L. Aistrup, J. E. Kelly, S. Kapur, M. Kowalczyk, I. Sysman-Wolpin, A. H. Kadish, and J. A. Wasserstrom
Pacing-induced Heterogeneities in Intracellular Ca2+ Signaling, Cardiac Alternans, and Ventricular Arrhythmias in Intact Rat Heart
Circ. Res., September 29, 2006; 99(7): E65 - E73.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
D. Sato, Y. Shiferaw, A. Garfinkel, J. N. Weiss, Z. Qu, and A. Karma
Spatially Discordant Alternans in Cardiac Tissue: Role of Calcium Cycling
Circ. Res., September 1, 2006; 99(5): 520 - 527.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. H. W. J. ten Tusscher and A. V. Panfilov
Alternans and spiral breakup in a human ventricular tissue model
Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1088 - H1100.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
H. Bien, L. Yin, and E. Entcheva
Calcium Instabilities in Mammalian Cardiomyocyte Networks
Biophys. J., April 1, 2006; 90(7): 2628 - 2640.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
J. L. Greenstein, R. Hinch, and R. L. Winslow
Mechanisms of Excitation-Contraction Coupling in an Integrative Model of the Cardiac Ventricular Myocyte
Biophys. J., January 1, 2006; 90(1): 77 - 91.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. G. Priori, S. V. Pandit, I. Rivolta, O. Berenfeld, E. Ronchetti, A. Dhamoon, C. Napolitano, J. Anumonwo, M. R. di Barletta, S. Gudapakkam, et al.
A Novel Form of Short QT Syndrome (SQT3) Is Caused by a Mutation in the KCNJ2 Gene
Circ. Res., April 15, 2005; 96(7): 800 - 807.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
T. J. Hund and Y. Rudy
Rate Dependence and Regulation of Action Potential and Calcium Transient in a Canine Cardiac Ventricular Cell Model
Circulation, November 16, 2004; 110(20): 3168 - 3174.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. C. Hao, D. J. Christini, K. M. Stein, P. N. Jordan, S. Iwai, O. Bramwell, S. M. Markowitz, S. Mittal, and B. B. Lerman
Effect of {beta}-adrenergic blockade on dynamic electrical restitution in vivo
Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H390 - H394.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. M. Cherry and F. H. Fenton
Suppression of alternans and conduction blocks despite steep APD restitution: electrotonic, memory, and conduction velocity restitution effects
Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2332 - H2341.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
F. Hua, D. C. Johns, and R. F. Gilmour Jr.
Suppression of electrical alternans by overexpression of HERG in canine ventricular myocytes
Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2342 - H2351.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Omichi, S. T. Lamp, S.-F. Lin, J. Yang, A. Baher, S. Zhou, M. Attin, M.-H. Lee, H. S. Karagueuzian, B. Kogan, et al.
Intracellular Ca dynamics in ventricular fibrillation
Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1836 - H1844.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
F. Hua and R. F. Gilmour Jr
Contribution of IKr to Rate-Dependent Action Potential Dynamics in Canine Endocardium
Circ. Res., April 2, 2004; 94(6): 810 - 819.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
Y. Shiferaw, M. A. Watanabe, A. Garfinkel, J. N. Weiss, and A. Karma
Model of Intracellular Calcium Cycling in Ventricular Myocytes
Biophys. J., December 1, 2003; 85(6): 3666 - 3686.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
P. Kirchhof, H. Degen, M. R. Franz, L. Eckardt, L. Fabritz, P. Milberg, S. Laer, J. Neumann, G. Breithardt, and W. Haverkamp
Amiodarone-Induced Postrepolarization Refractoriness Suppresses Induction of Ventricular Fibrillation
J. Pharmacol. Exp. Ther., April 1, 2003; 305(1): 257 - 263.
[Abstract] [Full Text]

Home page
 Cardiovasc ResHome page
M. L Walker and D. S Rosenbaum
Repolarization alternans: implications for the mechanism and prevention of sudden cardiac death
Cardiovasc Res, March 1, 2003; 57(3): 599 - 614.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Cabo and P. A. Boyden
Electrical remodeling of the epicardial border zone in the canine infarcted heart: a computational analysis
Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H372 - H384.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
J. L. Greenstein and R. L. Winslow
An Integrative Model of the Cardiac Ventricular Myocyte Incorporating Local Control of Ca2+ Release
Biophys. J., December 1, 2002; 83(6): 2918 - 2945.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. J. Fox, M. L. Riccio, F. Hua, E. Bodenschatz, and R. F. Gilmour Jr
Spatiotemporal Transition to Conduction Block in Canine Ventricle
Circ. Res., February 22, 2002; 90(3): 289 - 296.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online