AJP - Heart Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 282: H547-H555, 2002; doi:10.1152/ajpheart.01019.2000
0363-6135/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Meij, J. T. A.
Right arrow Articles by Cattini, P. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meij, J. T. A.
Right arrow Articles by Cattini, P. A.
Vol. 282, Issue 2, H547-H555, February 2002

Exacerbation of myocardial injury in transgenic mice overexpressing FGF-2 is T cell dependent

Johanna T. A. Meij1, Farah Sheikh1, Sarah K. Jimenez1, Peter W. Nickerson2, Elissavet Kardami3,4, and Peter A. Cattini1

Departments of 1 Physiology, 2 Internal Medicine and Immunology, and 3 Human Anatomy and Cell Science, University of Manitoba, Winnipeg R3E 3J7; and 4 Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada R2H 2A6

Fibroblast growth factor-2 (FGF-2) is cardioprotective when added exogenously, stimulates cardiac myocyte proliferation, and is a mediator of tissue repair after injury. Furthermore, transgenic (TG) mice overexpressing FGF-2 in cardiac muscle demonstrate increased resistance to injury in an isolated heart model of ischemia-reperfusion. We investigated how increasing the endogenous FGF-2 levels in the heart affects the extent of myocardial damage induced by isoproterenol in vivo. Histopathological evaluation of hearts after intraperitoneal injection of isoproterenol yielded significantly higher scores for myocardial damage in FGF-2 TG lines compared with non-TG mice. After 1 day, FGF-2 TG mouse hearts displayed more cellular infiltration correlating with increased tissue damage. Immunostaining of non-TG and FGF-2 TG mouse hearts showed the presence of leukocytes in the infiltrate, including T cells expressing FGF receptor-1. Treatment of mice with T cell suppressors cyclosporin A and anti-CD3epsilon significantly decreased the level of myocardial injury observed after isoproterenol and equalized the histopathology scores in FGF-2 TG and non-TG hearts. These data demonstrate a direct T cell involvement in the response to isoproterenol-induced injury in vivo. Moreover, the findings indicate that the exacerbation of myocardial damage in FGF-2 TG mice was dependent on T cell infiltration, implicating FGF-2 in the inflammatory response seen in cardiac tissue after injury in vivo.

myocardium; lymphocytes


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
D. J. Hausenloy and D. M. Yellon
Cardioprotective growth factors
Cardiovasc Res, July 15, 2009; 83(2): 179 - 194.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
Y. Mizukami, K. Ono, C.-K. Du, T. Aki, N. Hatano, Y. Okamoto, Y. Ikeda, H. Ito, K. Hamano, and S. Morimoto
Identification and physiological activity of survival factor released from cardiomyocytes during ischaemia and reperfusion
Cardiovasc Res, September 1, 2008; 79(4): 589 - 599.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
H. F. Rosenberg
Interview with Dr. Andrew Issekutz regarding Pivotal Advance: Endothelial growth factors VEGF and bFGF differentially modulate monocyte and neutrophil recruitment to inflammation
J. Leukoc. Biol., August 1, 2006; 80(2): 245 - 246.
[Full Text] [PDF]

Home page
 Cardiovasc ResHome page
K. A. Detillieux, F. Sheikh, E. Kardami, and P. A. Cattini
Biological activities of fibroblast growth factor-2 in the adult myocardium
Cardiovasc Res, January 1, 2003; 57(1): 8 - 19.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online