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Am J Physiol Heart Circ Physiol 282: H1063-H1070, 2002; doi:10.1152/ajpheart.00633.2001
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Vol. 282, Issue 3, H1063-H1070, March 2002

Effects of amiodarone on wave front dynamics during ventricular fibrillation in isolated swine right ventricle

Chikaya Omichi1, Shengmei Zhou1, Moon-Hyoung Lee1, Ajay Naik1, Che-Ming Chang1, Alan Garfinkel2, James N. Weiss2, Shien-Fong Lin3, Hrayr S. Karagueuzian1, and Peng-Sheng Chen1

1 Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, and 2 Division of Cardiology, Departments of Medicine, Physiology, and Physiological Science and the Cardiovascular Research Laboratory, University of California at Los Angeles School of Medicine, Los Angeles, California 90048-1865; and 3 Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235

The effects of acute amiodarone infusion on dynamics of ventricular fibrillation (VF) are unclear. Six isolated swine right ventricles (RVs) were studied in vitro. Activation patterns during VF were mapped optically, whereas action potentials were recorded with a glass microelectrode. At baseline, VF was associated with frequent spontaneous wave breaks. Amiodarone (2.5 µg/ml) reduced spontaneous wave breaks and increased the cycle length (CL) of VF from 83.3 ± 17.8 ms at baseline to 118.4 ± 25.8 ms during infusion (P < 0.05). Amiodarone increased the reentrant wave front CL (114.4 ± 15.5 vs. 78.2 ± 19.0 ms, P < 0.05) and central core area (4.1 ± 3.8 vs. 0.9 ± 0.3 mm2, P < 0.05). Within 30 min of infusion, VF terminated (n = 1), converted to ventricular tachycardia (VT) (n = 1) or continued at a slower rate (n = 4). Amiodarone flattened the APD restitution curves. We conclude that amiodarone reduced spontaneous wave breaks. It might terminate VF or convert VF to VT. These effects were associated with the flattening of APD restitution slope and increased core size of reentrant wave fronts.

optical mapping; action potential duration restitution; sudden death; pharmacology; antiarrhythmic agents


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