AJP - Heart Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 282: H1081-H1091, 2002; doi:10.1152/ajpheart.00498.2001
0363-6135/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shimizu, J.
Right arrow Articles by Burkhoff, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shimizu, J.
Right arrow Articles by Burkhoff, D.
Vol. 282, Issue 3, H1081-H1091, March 2002

Load dependence of ventricular performance explained by model of calcium-myofilament interactions

Juichiro Shimizu, Koji Todaka, and Daniel Burkhoff

Division of Circulatory Physiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032

Although a simple concept of load-independent behavior of the intact heart evolved from early studies of isolated, intact blood-perfused hearts, more recent studies showed that, as in isolated muscle, the mode of contraction (isovolumic vs. ejection) impacts on end-systolic elastance. The purpose of the present study was to test whether a four-state model of myofilament interactions with length-dependent rate constants could explain the complex contractile behavior of the intact, ejecting heart. Studies were performed in isolated, blood-perfused canine hearts with intracellular calcium transients measured by macroinjected aequorin. Measured calcium transients were used as the driving function for the model, and length-dependent rate constants yielding the highest concordance between measured and model-predicted midwall stress at different isovolumic volumes were determined. These length-dependent rate constants successfully predicted contractile behavior on ejecting contractions. This, along with additional model analysis, suggests that length-dependent changes in calcium binding affinity may not be an important factor contributing to load-dependent contractile performance in the intact heart under physiological conditions.

left ventricle; calcium transient; four-state model; excitation-contraction coupling


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
K. B. Campbell, A. M. Simpson, S. G. Campbell, H. L. Granzier, and B. K. Slinker
Dynamic left ventricular elastance: a model for integrating cardiac muscle contraction into ventricular pressure-volume relationships
J Appl Physiol, April 1, 2008; 104(4): 958 - 975.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. A. MacGowan, J. A. Kirk, C. Evans, and S. G. Shroff
Pressure-calcium relationships in perfused mouse hearts
Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2614 - H2624.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
V. Saks, P. Dzeja, U. Schlattner, M. Vendelin, A. Terzic, and T. Wallimann
Cardiac system bioenergetics: metabolic basis of the Frank-Starling law
J. Physiol., March 1, 2006; 571(2): 253 - 273.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
R. Ventura-Clapier, A. Garnier, and V. Veksler
Energy metabolism in heart failure
J. Physiol., February 15, 2004; 555(1): 1 - 13.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. S. Rhodes, K. M. Ropella, S. H. Audi, A. K. S. Camara, L. G. Kevin, P. S. Pagel, and D. F. Stowe
Cross-bridge kinetics modeled from myoplasmic [Ca2+] and LV pressure at 17{degrees}C and after 37{degrees}C and 17{degrees}C ischemia
Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1217 - H1229.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online