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Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka 565-8565, Japan
A transfer function
from baroreceptor pressure input to sympathetic nerve activity (SNA)
shows derivative characteristics in the frequency range below 0.8 Hz in
rabbits. These derivative characteristics contribute to a quick and
stable arterial pressure (AP) regulation. However, if the derivative
characteristics hold up to heart rate frequency, the pulsatile pressure
input will yield a markedly augmented SNA signal. Such a signal would
saturate the baroreflex signal transduction, thereby disabling the
baroreflex regulation of AP. We hypothesized that the transfer gain at
heart rate frequency would be much smaller than that predicted from extrapolating the derivative characteristics. In anesthetized rabbits
(n = 6), we estimated the neural arc transfer function in the frequency range up to 10 Hz. The transfer gain was lost at a
rate of 
20 dB/decade when the input frequency exceeded 0.8 Hz. A
numerical simulation indicated that the high-cut characteristics above
0.8 Hz were effective to attenuate the pulsatile signal and preserve
the open-loop gain when the baroreflex dynamic range was finite.
systems analysis; transfer function; simulation; carotid sinus baroreflex; frequency-dependent depression
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