AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 282: H918-H925, 2002; doi:10.1152/ajpheart.00641.2001
0363-6135/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wong, A. Y. H.
Right arrow Articles by Adamson, S. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wong, A. Y. H.
Right arrow Articles by Adamson, S. L.
Vol. 282, Issue 3, H918-H925, March 2002

Maternal cardiovascular changes during pregnancy and postpartum in mice

Alan Y. H. Wong1,2,3, Shathiyah Kulandavelu1,2,3, Kathie J. Whiteley1, Dawei Qu1, B. Lowell Langille1,2,4, and S. Lee Adamson1,2,3

1 Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto, M5G 1X5, and Departments of 2 Obstetrics and Gynecology, 3 Physiology, and 4 Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

Genetically altered mice may provide useful models for exploring cardiovascular regulation during pregnancy and postpartum if changes in mice mimic humans. We found in awake ICR (CD-1) mice at 17.5 days gestation that hematocrit was reduced 18%, and the pressor response to intravenous angiotensin II was reduced ~33%. Arterial pressure in awake mice was 12% lower in early pregnancy (3.5 days) than late pregnancy (17.5 days) and postpartum (3 and 17 days after delivery), whereas heart rate was 10-20% higher in the peripartum period (17.5 days gestation and 3 days postpartum). In late pregnancy, cardiac output under isoflurane anesthesia was 64% higher than in nonpregnant mice, due to a 37% increase in stroke volume and a 17% increase in heart rate. All changes P < 0.05. We conclude that, as in humans, mice exhibit hypotension in early pregnancy, and a blunted pressor response to angiotensin II, a decrease in hematocrit, and a marked increase in cardiac output in late pregnancy.

cardiac output; blood pressure; angiotensin; hematocrit; heart rate; Doppler ultrasound; aortic blood velocity waveform


This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
B.M Acton, I Lai, X Shang, A Jurisicova, and R.F Casper
Neutral Mitochondrial Heteroplasmy Alters Physiological Function in Mice
Biol Reprod, September 1, 2007; 77(3): 569 - 576.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
S. Kulandavelu, D. Qu, and S. L. Adamson
Cardiovascular Function in Mice During Normal Pregnancy and in the Absence of Endothelial NO Synthase
Hypertension, June 1, 2006; 47(6): 1175 - 1182.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. Perlegas, H. Xie, S. Sinha, A. V. Somlyo, and G. K. Owens
ANG II type 2 receptor regulates smooth muscle growth and force generation in late fetal mouse development
Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H96 - H102.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
O. W. H. van der Heijden, Y. P. G. Essers, L. H. J. Simkens, Q. G. A. Teunissen, L. L. H. Peeters, J. G. R. De Mey, and G. J. J. M. van Eys
Aging Blunts Remodeling of the Uterine Artery During Murine Pregnancy
Reproductive Sciences, July 1, 2004; 11(5): 304 - 310.
[Abstract] [PDF]

Home page
 Biol. Reprod.Home page
C.-L. M. Cooke and S. T. Davidge
Pregnancy-Induced Alterations of Vascular Function in Mouse Mesenteric and Uterine Arteries
Biol Reprod, March 1, 2003; 68(3): 1072 - 1077.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online