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Am J Physiol Heart Circ Physiol 282: H942-H948, 2002; doi:10.1152/ajpheart.00724.2001
0363-6135/02 $5.00
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Vol. 282, Issue 3, H942-H948, March 2002

Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension

Iveta Bernátová1, Olga Pechánová1, Pavel Babál2, Sona Kyselá1, Svetoslav Stvrtina2, and Ramaroson Andriantsitohaina3

1 Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 813 71 Bratislava; 2 Department of Pathology, Medical Faculty, Comenius University, 81108 Bratislava, Slovak Republic; and 3 Pharmacologie et Physico-Chimie des Interactions Cellulaires et Moléculaires, Université Louis Pasteur de Strasbourg, Unité Mixte de Recherche Centre National de la Recherche Scientifique 7034, Faculté de Pharmacie, Illkirch, France

The effects of the red wine polyphenolic compounds (Provinol) on hypertension, left ventricular hypertrophy, myocardial fibrosis, and vascular remodeling were investigated after chronic inhibition of nitric oxide (NO) synthase by administration of NG-nitro-L-arginine methyl ester (L-NAME) to rats. Rats were divided into four groups: a control group, a group treated for 4 wk with L-NAME (40 mg · kg-1 · day-1), and two groups treated with L-NAME followed by 3 wk of either spontaneous recovery or recovery with Provinol treatment (40 mg · kg-1 · day-1). Administration of Provinol produced a greater readiness of the decrease in blood pressure than that in the spontaneous recovery group. Provinol significantly depressed myocardial fibrosis and expedited the decrease in aortic cross-sectional area, the increase in endothelium-dependent relaxation, and the decrease in contraction of the aorta. These effects of Provinol were associated with a greater increase of NO synthase activity in the left ventricle and the aorta. The present study provides evidence that Provinol accelerates the regression of blood pressure and improves structural and functional cardiovascular changes produced by chronic inhibition of NO synthesis.

nitric oxide synthase; myocardial fibrosis; aortic stiffness


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