| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Pharmacology and 2 Department of Hematology, Institut National de la Santé et de la Recherche Médicale E9920, Institut Fédératif de Recherche Multidisciplinaire Sur les Peptides No. 23, Rouen University Hospital, 76031 Rouen, France
To assess the influence of initial diameter on the gender difference in flow-dependent dilatation (FDD) of the conduit artery, we measured radial artery internal diameter (echotracking), flow (Doppler) and total blood viscosity in 24 healthy (25 ± 0.8 yr) men and women during reactive hyperemia (RH) and during a gradual hand skin heating (SH). At baseline, mean diameter (men, 2.76 ± 0.09 vs. women, 2.32 ± 0.07 mm, P < 0.05), flow (men, 21 ± 4 vs. women, 10 ± 1 ml/min, P < 0.05), and blood viscosity (men, 4.13 ± 0.07 vs. women, 3.92 ± 0.13 cP, P < 0.05) were higher in men but mean shear stress (MSS) was not different between groups. During RH, the percent increase in diameter was lower in men (men, 9 ± 1 vs. women, 13 ± 1%, P < 0.05). This difference was suppressed after correction for baseline diameter. During SH, the increase in diameter with flow was higher in women (P < 0.01). However, the increase in MSS was higher in women because of their smaller diameter at each level of flow (P < 0.01) and there was no difference between groups for the increase in diameter at each level of MSS. These results demonstrate in a direct manner that initial diameter influences the magnitude of FDD of conduit arteries in humans by modifying the value of the arterial wall shear stress at each level of flow and support the interest of the heating method in presence of heterogeneous groups.
endothelium; shear stress; skin heating; vasodilatation
This article has been cited by other articles:
|
|
 |
|
  K. S Heffernan, R. H Karas, P. J Mooney, A. R Patel, and J. T Kuvin Pulse wave amplitude is associated with brachial artery diameter: Implications for gender differences in microvascular function Vascular Medicine, February 1, 2010; 15(1): 39 - 45. [Abstract] [PDF]
|
|
|
|
 |
|
 B. J. Wong, G. Simmons, C. Bopp, J. Yeboah, D. P. Casey, C. Austin, H. Tanaka, A. E. DeVan, J. N. Barnes, G. Atkinson, et al. Commentaries on viewpoint: pick your Poiseuille: normalizing the shear stimulus in studies of flow-mediated dilation. J Appl Physiol, October 1, 2009; 107(4): 1360 - 1361. [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. J. Thijssen, E. A. Dawson, M. A. Black, M. T. E. Hopman, N. T. Cable, and D. J. Green Heterogeneity in conduit artery function in humans: impact of arterial size Am J Physiol Heart Circ Physiol, November 1, 2008; 295(5): H1927 - H1934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Nishiyama, D. W. Wray, and R. S. Richardson Sex and limb-specific ischemic reperfusion and vascular reactivity Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1100 - H1108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Pyke, J. A. Hartnett, and M. E. Tschakovsky Are the dynamic response characteristics of brachial artery flow-mediated dilation sensitive to the magnitude of increase in shear stimulus? J Appl Physiol, July 1, 2008; 105(1): 282 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Pyke, V. Poitras, and M. E. Tschakovsky Brachial artery flow-mediated dilation during handgrip exercise: evidence for endothelial transduction of the mean shear stimulus Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2669 - H2679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Pyke and M. E. Tschakovsky Peak vs. total reactive hyperemia: which determines the magnitude of flow-mediated dilation? J Appl Physiol, April 1, 2007; 102(4): 1510 - 1519. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E Pyke and M. E Tschakovsky The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function J. Physiol., October 15, 2005; 568(2): 357 - 369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Silber, P. Ouyang, D. A. Bluemke, S. N. Gupta, T. K. Foo, and J. A. C. Lima Why is flow-mediated dilation dependent on arterial size? Assessment of the shear stimulus using phase-contrast magnetic resonance imaging Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H822 - H828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Pyke, E. M. Dwyer, and M. E. Tschakovsky Impact of controlling shear rate on flow-mediated dilation responses in the brachial artery of humans J Appl Physiol, August 1, 2004; 97(2): 499 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Stoner, M. Sabatier, K. Edge, and K. McCully Relationship between blood velocity and conduit artery diameter and the effects of smoking on vascular responsiveness J Appl Physiol, June 1, 2004; 96(6): 2139 - 2145. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
