| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of 1 Cardiology and 2 Pediatrics (Pediatric Cardiology), Leiden University Medical Center, 2300 RC Leiden; and 3 Department of Pediatric Cardiology, Erasmus Medical Center-Sophia Children's Hospital, 3000 CB Rotterdam, The Netherlands
Diastolic function is a major
determinant of ventricular performance, especially when loading
conditions are altered. We evaluated biventricular diastolic function
in lambs and studied possible load dependence of diastolic parameters
[minimum first derivative of pressure vs. time
(dP/dtmin) and time constant of isovolumic relaxation (
)] in normal (n = 5) and chronic right
ventricular (RV) pressure-overloaded (n = 5) hearts by
using an adjustable band on the pulmonary artery (PAB). Pressure-volume
relations were measured during preload reduction to obtain the
end-diastolic pressure-volume relationship (EDPVR). In normal lambs,
absolute dP/dtmin and were lower in the RV
than in the left ventricle whereas the chamber stiffness constant
(b) was roughly the same. After PAB, RV and
dP/dtmin were significantly higher compared with
control. The RV EDPVR indicated impaired diastolic function. During
acute pressure reduction, both dP/dtmin and showed a relationship with end-systolic pressure. These relationships
could explain the increased dP/dtmin but not the
increased -value after banding. Therefore, the increased after
banding reflects intrinsic myocardial changes. We conclude that after
chronic RV pressure overload, RV early relaxation is prolonged and
diastolic stiffness is increased, both indicative of impaired diastolic function.
hemodynamics; hypertrophy; pressure-volume relation; ventricular function, diastole
This article has been cited by other articles:
|
|
 |
|
  F. Haddad, S. A. Hunt, D. N. Rosenthal, and D. J. Murphy Right Ventricular Function in Cardiovascular Disease, Part I: Anatomy, Physiology, Aging, and Functional Assessment of the Right Ventricle Circulation, March 18, 2008; 117(11): 1436 - 1448. [Full Text] [PDF]
|
|
|
|
 |
|
 G. Acharya, J. Rasanen, K. Makikallio, T. Erkinaro, T. Kavasmaa, M. Haapsamo, L. Mertens, and J. C. Huhta Metabolic acidosis decreases fetal myocardial isovolumic velocities in a chronic sheep model of increased placental vascular resistance Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H498 - H504. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. T.-J. Gan, S. Holverda, J. T. Marcus, W. J. Paulus, K. M. Marques, J. G.F. Bronzwaer, J. W. Twisk, A. Boonstra, P. E. Postmus, and A. Vonk-Noordegraaf Right Ventricular Diastolic Dysfunction and the Acute Effects of Sildenafil in Pulmonary Hypertension Patients Chest, July 1, 2007; 132(1): 11 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. M. Hessel, P. Steendijk, B. den Adel, C. I. Schutte, and A. van der Laarse Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2424 - H2430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A.F. Tulner, P. Steendijk, R. J.M. Klautz, J. J. Bax, M. J. Schalij, E. E. van der Wall, and R. A.E. Dion Surgical ventricular restoration in patients with ischemic dilated cardiomyopathy: Evaluation of systolic and diastolic ventricular function, wall stress, dyssynchrony, and mechanical efficiency by pressure-volume loops. J. Thorac. Cardiovasc. Surg., September 1, 2006; 132(3): 610 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Stoica, D. K. Satchithananda, P. A. White, L. Sharples, J. Parameshwar, A. N. Redington, and S. R. Large Brain death leads to abnormal contractile properties of the human donor right ventricle J. Thorac. Cardiovasc. Surg., July 1, 2006; 132(1): 116 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G B Bleeker, P Steendijk, E R Holman, C-M Yu, O A Breithardt, T A M Kaandorp, M J Schalij, E E van der Wall, P Nihoyannopoulos, and J J Bax Assessing right ventricular function: the role of echocardiography and complementary technologies Heart, April 1, 2006; 92(suppl_1): i19 - i26. [Full Text] [PDF]
|
|
|
|
|
|
S. L. Gaynor, H. S. Maniar, J. B. Bloch, P. Steendijk, and M. R. Moon Right Atrial and Ventricular Adaptation to Chronic Right Ventricular Pressure Overload Circulation, August 30, 2005; 112(9_suppl): I-212 - I-218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. J. Leeuwenburgh, P. H. Schoof, P. Steendijk, J. Baan, W. J. Mooi, and W. A. Helbing Reply to the editor J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 2105 - 2106. [Full Text] [PDF]
|
|
|
|
|
|
B. P. J. Leeuwenburgh, W. A. Helbing, P. Steendijk, P. H. Schoof, and J. Baan Effects of acute left ventricular unloading on right ventricular function in normal and chronic right ventricular pressure-overloaded lambs J. Thorac. Cardiovasc. Surg., March 1, 2003; 125(3): 481 - 490. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
