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Am J Physiol Heart Circ Physiol 282: H1592-H1602, 2002; doi:10.1152/ajpheart.00222.2001
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Vol. 282, Issue 5, H1592-H1602, May 2002

Central mechanisms of acute ANG II modulation of arterial baroreflex control of renal sympathetic nerve activity

Max G. Sanderford1 and Vernon S. Bishop2

1 Department of Biological Sciences, Tarleton State University, Stephenville 76401; and 2 Department of Physiology, University of Texas Health Science Center, San Antonio, Texas 78229-3900

Short-term intravenous infusion of angiotensin II (ANG II) into conscious rabbits reduces the range of renal sympathetic nerve activity (RSNA) by attenuating reflex disinhibition of RSNA. This action of ANG II to attenuate the arterial baroreflex range is exaggerated when ANG II is directed into the vertebral circulation, which suggests a mechanism involving the central nervous system. Because an intact area postrema (AP) is required for ANG II to attenuate arterial baroreflex-mediated bradycardia and is also required for maintenance of ANG II-dependent hypertension, we hypothesized that attenuation of maximum RSNA during infusion of ANG II involves the AP. In conscious AP-lesioned (APX) and AP-intact rabbits, we compared the effect of a 5-min intravenous infusion of ANG II (10 and 20 ng · kg-1 · min-1) on the relationship between mean arterial blood pressure (MAP) and RSNA. Intravenous infusion of ANG II into AP-intact rabbits resulted in a dose-related attenuation of maximum RSNA observed at low MAP. In contrast, ANG II had no effect on maximum RSNA in APX rabbits. To further localize the central site of ANG II action, its effect on the arterial baroreflex was assessed after a midcollicular decerebration. Decerebration did not alter arterial baroreflex control of RSNA compared with the control state, but as in APX, ANG II did not attenuate the maximum RSNA observed at low MAP. The results of this study indicate that central actions of peripheral ANG II to attenuate reflex disinhibition of RSNA not only involve the AP, but may also involve a neural interaction rostral to the level of decerebration.

circulating peptides; renal nerves; sympathetic nervous system; blood pressure; kidney


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