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Am J Physiol Heart Circ Physiol 282: H1603-H1608, 2002. First published November 8, 2001; doi:10.1152/ajpheart.00786.2001
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Vol. 282, Issue 5, H1603-H1608, May 2002

Effect of repeated episodes of reversible myocardial ischemia on myocardial blood flow and function in humans

Edward Barnes, David P. Dutka, Masood Khan, Paolo G. Camici, and Roger J. Hall

Division of Cardiology and Medical Research Council Clinical Sciences Centre and National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, United Kingdom W12 0NN

Nine patients with coronary artery disease and normal left ventricular (LV) function underwent two episodes of dobutamine-induced ischemia to determine whether repeated episodes of ischemia lead to cumulative stunning. Positron emission tomography (PET) and oxygen 15-labeled H2O was used to assess myocardial blood flow (MBF) at baseline, peak stress, and after stress for each ischemic episode. Quantitative echocardiographic assessment of global ejection fraction (EF) and regional systolic function (SF) was performed at rest and regular intervals after dobutamine. SF was assessed for regions subtended by a coronary artery with a >70% diameter stenosis. Both EF and SF were more severely impaired 45 min after the second episode of stress compared with 45 min after the first (both P < 0.01), despite no difference in duration of the two dobutamine infusions or MBF at peak stress (1.72 vs. 1.69). After both episodes of ischemia, when LV function was impaired but subsequently recovered, MBF (1.15 ± 0.39 and 1.20 ± 0.43, respectively) was no different to baseline MBF (1.02 ± 0.35), confirming that repeated episodes of dobutamine-induced ischemia lead to cumulative myocardial stunning.

myocardial stunning; coronary artery disease


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