| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Departments of Medicine and 2 Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032; 3 IMPULSE Dynamics, Tirat Hacarmel, 39120; and 4 Department of Physiology And Biophysics, Technion-Israel Institute of Technology, Haifa 31096, Israel
Inotropic effects of electric currents applied during the refractory period have been reported in cardiac muscle in vitro using voltage-clamp techniques. We investigated how electric currents modulate cardiac contractility in normal canine hearts in vivo. Six dogs were instrumented to measure regional segment length, ventricular volume (sonomicrometry), and ventricular pressure. Cardiac contractility modulating (CCM) electric currents (biphasic square pulses, amplitude ±20 mA, total duration 30 ms) were delivered during the refractory period between pairs of electrodes placed on anterior and posterior walls. CCM significantly increased index of global contractility (Ees) from 5.9 ± 2.9 to 8.3 ± 4.6 mmHg/ml with anterior CCM, from 5.3 ± 1.8 to 8.9 ± 4.0 mmHg/ml with posterior CCM, and from 6.1 ± 2.6 to 11.0 ± 7.0 mmHg/ml with combined CCM (P < 0.01, no significant change in volume axis intercept). End-systolic pressure-segment length relations showed contractility enhancement near CCM delivery sites, but not remotely. Relaxation was not influenced. CCM increased mean aortic pressure, but did not change peripheral resistance. Locally applied electrical currents enhanced global cardiac contractility via regional changes in myocardial contractility without impairing relaxation in situ.
canine heart; calcium; in situ heart failure; voltage clamping
This article has been cited by other articles:
|
|
 |
|
  C. Butter, S. Rastogi, H.-H. Minden, J. Meyhofer, D. Burkhoff, and H. N. Sabbah Cardiac Contractility Modulation Electrical Signals Improve Myocardial Gene Expression in Patients With Heart Failure J. Am. Coll. Cardiol., May 6, 2008; 51(18): 1784 - 1789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Daubert Modulation of cardiac contractility. A potential treatment of heart failure? Eur. Heart J., April 2, 2008; 29(8): 961 - 963. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Butter, J. Meyhofer, M. Seifert, M. Neuss, and H.-H. Minden First use of cardiac contractility modulation (CCM) in a patient failing CRT therapy: Clinical and technical aspects of combined therapies Eur J Heart Fail, September 1, 2007; 9(9): 955 - 958. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Oshima, S. Mohri, J. Shimizu, G. Iribe, T. Imaoka, W. Fujinaka, T. Kiyooka, K. Ishino, S. Sano, F. Kajiya, et al. Celsior Preserved Cardiac Mechanoenergetics Better Than Popular Solutions in Canine Hearts Ann. Thorac. Surg., February 1, 2006; 81(2): 658 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Brunckhorst, I. Shemer, Y. Mika, S. A. Ben-Haim, and D. Burkhoff Cardiac contractility modulation by non-excitatory currents: Studies in isolated cardiac muscle Eur J Heart Fail, January 1, 2006; 8(1): 7 - 15. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Lawo, M. Borggrefe, C. Butter, G. Hindricks, H. Schmidinger, Y. Mika, D. Burkhoff, C. Pappone, and H. N. Sabbah Electrical Signals Applied During the Absolute Refractory Period: An Investigational Treatment for Advanced Heart Failure in Patients With Normal QRS Duration J. Am. Coll. Cardiol., December 20, 2005; 46(12): 2229 - 2236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Burkhoff and S. A. Ben-Haim Nonexcitatory electrical signals for enhancing ventricular contractility: rationale and initial investigations of an experimental treatment for heart failure Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2550 - H2556. [Full Text] [PDF]
|
|
|
|
|
|
G. Stix, M. Borggrefe, C. Wolpert, G. Hindricks, H. Kottkamp, D. Bocker, T. Wichter, Y. Mika, S. Ben-Haim, D. Burkhoff, et al. Chronic electrical stimulation during the absolute refractory period of the myocardium improves severe heart failure Eur. Heart J., April 2, 2004; 25(8): 650 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Peles, J. Petersen, R. Aviv, S. Policker, O. Abu-Hatoum, S. A. Ben-Haim, D. D. Gutterman, and J. N. Sengupta Enhancement of antral contractions and vagal afferent signaling with synchronized electrical stimulation Am J Physiol Gastrointest Liver Physiol, August 8, 2003; 285(3): G577 - G585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mohri, J. Shimizu, Y. Mika, I. Shemer, J. Wang, S. Ben-Haim, and D. Burkhoff Electric currents applied during refractory period enhance contractility and systolic calcium in the ferret heart Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1119 - H1123. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
