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1 Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine; and 2 Department of Echocardiography, School of Allied Health Science, Osaka University Faculty of Medicine, Osaka 565-0871, Japan
We characterized
the time course of the left ventricular (LV) geometric and functional
changes after aortic banding, validated them by necropsy, and
investigated the sensitivity of echocardiographic findings on LV
hypertrophy. C57BL/6 mice were subjected to transverse aortic
constriction (TAC) or sham operation; echocardiographic assessments
were performed before or at 2, 4, 6, and 11 wk after surgery; and some
of the mice were euthanized at the corresponding time points. There was
a progressive increase in diastolic posterior wall thickness and LV
systolic dimension; the percentage of LV fractional shortening (LV%FS)
decreased progressively at 4 wk, whereas these parameters remained
stable in sham-operated mice. Echo LV mass and LV%FS correlated well
with actual whole heart mass and ratio of lung weight to body weight,
respectively (r = 0.765 and 
0.749, respectively;
P < 0.0001). These results suggest that the
development of myocardial hypertrophy and systolic dysfunction is a
time-dependent process. Echocardiographic assessment of myocardial hypertrophy and functional changes correlate well with the actual heart
mass and lung mass. Echocardiography is sensitive enough to assess
myocardial hypertrophy and heart functional changes induced by pressure
overload in mice.
myocardial; heart failure; left ventricular hypertrophy
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