AJP - Heart Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 282: H1898-H1906, 2002; doi:10.1152/ajpheart.00488.2001
0363-6135/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Francis, J.
Right arrow Articles by Felder, R. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Francis, J.
Right arrow Articles by Felder, R. B.
Vol. 282, Issue 5, H1898-H1906, May 2002

Forebrain-mediated adaptations to myocardial infarction in the rat

Joseph Francis2, Shun-Guang Wei2, Robert M. Weiss1,2, Terry Beltz3, Alan Kim Johnson3, and Robert B. Felder1,2

1 Department of Veterans Affairs Medical Center and Departments of 2 Internal Medicine and 3 Psychology, University of Iowa, Iowa City, Iowa 52242

Recent studies suggest that the forebrain contributes to the circulatory derangements leading to heart failure after myocardial injury. We tested that hypothesis by examining the effect of myocardial infarction (MI) or sham MI (MI-s) on neurohumoral regulation in rats with prior anteroventral (AV) third ventricle lesion (AV3V-x) or sham lesion (AV3V-s). AV3V-s/MI rats had higher sodium intake, lower urine volume, and lower urinary sodium excretion than AV3V-s/MI-s rats. AV3V-x/MI rats had lower sodium intake and higher urine volume than AV3V-s/MI or AV3V-s/MI-s rats and urinary sodium excretion comparable to AV3V-s/MI-s rats. AV3V-x had no effect on baseline plasma renin activity (PRA). One week after MI, PRA had increased in AV3V-s but decreased in AV3V-x rats. AV3V-x reduced renal sympathetic nerve activity in MI and MI-s rats. AV3V-x improved baroreflex function in MI rats but diminished it in MI-s rats. Survival beyond 2 wk was lower in the AV3V-x/MI rats than in all other groups. These results confirm a critical role for the forebrain in the neurohumoral adjustments to MI.

anteroventral third ventricle; baroreflex; sympathetic drive; volume regulation; plasma renin activity


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Francis, S.-G. Wei, R. M. Weiss, and R. B. Felder
Brain angiotensin-converting enzyme activity and autonomic regulation in heart failure
Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2138 - H2146.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Francis, Z.-H. Zhang, R. M. Weiss, and R. B. Felder
Neural regulation of the proinflammatory cytokine response to acute myocardial infarction
Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H791 - H797.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Francis, T. Beltz, A. K. Johnson, and R. B. Felder
Mineralocorticoids act centrally to regulate blood-borne tumor necrosis factor-{alpha} in normal rats
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2003; 285(6): R1402 - R1409.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. R. De Smet, M. F. Menadue, J. R. Oliver, and P. A. Phillips
Increased thirst and vasopressin secretion after myocardial infarction in rats
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R1203 - R1211.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. B. Felder, J. Francis, Z.-H. Zhang, S.-G. Wei, R. M. Weiss, and A. K. Johnson
Heart failure and the brain: new perspectives
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R259 - R276.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Francis, R. M. Weiss, A. K. Johnson, and R. B. Felder
Central mineralocorticoid receptor blockade decreases plasma TNF-alpha after coronary artery ligation in rats
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R328 - R335.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online