| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-opioid receptor agonists on infarct size
reduction in swine
Departments of 1 Anesthesiology and 2 Physiology and the 3 Biomedical Engineering Institute, University of Minnesota, Minneapolis, Minnesota 55455; and 4 Department of Pathology, University of Kentucky, Lexington, Kentucky 40511
Opioids are involved in
cardiac ischemic preconditioning. Important species differences
in cellular signaling mechanisms, antiarrhythmic, and antistunning
effects have been described. The role of the 
-opioid receptor
activation in swine remains unknown. Forty minutes before a 45-min
occlusion and 180-min reperfusion of the left anterior descending
coronary artery, open-chest, pentobarbital-anesthetized swine
received either 1) saline (controls); 2)
[D-Ala2,D-Leu5]enkephalin
(DADLE); 3) [D-Pen2,5]enkephalin
(DPDPE); 4) deltorphin-D, a novel 2-opioid
agonist; or 5) ischemic preconditioning (IP).
Assessed were 1) infarct size to area at risk (IS,
triphenyltetrazolium staining), 2) regional and global
myocardial function (sonomicrometry, ventricular pressure catheters), and 3) arrhythmias (electrocardiogram analyses).
It was found that DPDPE and deltorphin-D pretreatment reduced
IS from 64.7 ± 5 to 36.5 ± 6% and 27.4 ± 11%
(P < 0.01), respectively, whereas DADLE had no effect
(66.8 ± 3%). Both IP and DADLE had a proarrhythmic effect
(P < 0.01). However, no differences in global or
regional myocardial function or arrhythmia scores were observed between
groups. This suggests that -receptor-specific opioids provide
cardioprotection in swine.
cardioprotection; myocardial ischemia; regional myocardial
function; arrhythmia; 
-opioid receptor
This article has been cited by other articles:
|
|
 |
|
  Y.-F. Xiao, D. C. Sigg, M. R. Ujhelyi, J. J. Wilhelm, E. S. Richardson, and P. A. Iaizzo Pericardial delivery of omega-3 fatty acid: a novel approach to reducing myocardial infarct sizes and arrhythmias Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2212 - H2218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-H. Huang, H.-Q. Wang, W. R. Roeske, Y. Birnbaum, Y. Wu, N.-P. Yang, Y. Lin, Y. Ye, D. J. McAdoo, M. G. Hughes, et al. Mediating {delta}-opioid-initiated heart protection via the beta2-adrenergic receptor: role of the intrinsic cardiac adrenergic cell Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H376 - H384. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Bovill Intravenous Anesthesia for the Patient with Left Ventricular Dysfunction Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2006; 10(1): 43 - 48. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Smith Sonneborn, H. Gottsch, E. Cubin, P. Oeltgen, and P. Thomas Alternative Strategy for Stress Tolerance: Opioids J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2004; 59(5): B433 - B440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kuzume, R. A. Wolff, K. Amakawa, K. Kuzume, and D. M. Van Winkle Sustained exogenous administration of Met5-enkephalin protects against infarction in vivo Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2463 - H2470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Menzebach, J. Hirsch, G. Hempelmann, and I. D. Welters Effects of endogenous and synthetic opioid peptides on neutrophil function in vitro Br. J. Anaesth., October 1, 2003; 91(4): 546 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Coles Jr., D. C. Sigg, and P. A. Iaizzo Role of kappa -opioid receptor activation in pharmacological preconditioning of swine Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2091 - H2099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Bovill Anesthesia for Patients with Impaired Ventricular Function Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2003; 7(1): 49 - 54. [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
