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Am J Physiol Heart Circ Physiol 282: H2216-H2223, 2002. First published February 14, 2002; doi:10.1152/ajpheart.00977.2001
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Vol. 282, Issue 6, H2216-H2223, June 2002

Effect of endurance training on coronary artery size and function in healthy men: an invasive followup study

Stephan Windecker, Yves Allemann, Michael Billinger, Tilmann Pohl, Damian Hutter, Thomas Orsucci, Laurent Blaga, Bernhard Meier, and Christian Seiler

Department of Cardiology, University Hospital, CH-3010 Bern, Switzerland

In eight healthy male volunteers (cardiologists; age 36 ± 5 yr), bicycle spiroergometry, Doppler echocardiography, and quantitative coronary angiography with intracoronary Doppler measurements before and after completion of a physical endurance exercise program of >5 mo duration were performed. Maximum oxygen uptake increased from 46 ± 6 to 54 ± 5 ml · kg-1 · min-1 (P = 0.04), maximum ergometric workload changed from 3.8 ± 0.3 to 4.4 ± 0.3 W/kg (P = 0.001), and left ventricular mass index increased from 82 ± 18 to 108 ± 29 g/m2 (P = 0.001). The right, left main, and left anterior descending coronary artery cross-sectional area increased significantly in repsonse to exercise. Before versus at the end of the exercise program, flow-induced left anterior descending coronary artery cross-sectional area was 10.1 ± 3.5 and 11.0 ± 3.9 mm2, respectively (P = 0.03), nitroglycerin-induced left coronary calibers increased significantly, and coronary flow velocity reserve changed from 3.8 ± 0.8 to 4.5 ± 0.7 (P = 0.001). Left coronary artery correlated significantly with ventricular mass and maximum oxygen uptake, and coronary flow velocity reserve was significantly associated with maximum workload.

coronary circulation; endothelial function; exercise


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