AJP - Heart Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 282: H2316-H2323, 2002; doi:10.1152/ajpheart.00763.2001
0363-6135/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (61)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nemoto, S.
Right arrow Articles by Mann, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nemoto, S.
Right arrow Articles by Mann, D. L.
Vol. 282, Issue 6, H2316-H2323, June 2002

Escherichia coli LPS-induced LV dysfunction: role of toll-like receptor-4 in the adult heart

Shintaro Nemoto1, Jesus G. Vallejo1,2,3, Pascal Knuefermann1,2, Arunima Misra1,2, Gilberto Defreitas1, Blase A. Carabello1, and Douglas L. Mann1,2

1 Department of Medicine, Houston Veterans Affairs Medical Center, 2 Winters Center for Heart Failure Research, and Section of Infectious Diseases, 3 Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030

The precise molecular mechanisms responsible for sepsis-induced myocardial dysfunction remain undefined. Toll-like receptor-4 (TLR-4) engages lipopolysaccharide (LPS) and activates signaling pathways leading to the expression of proinflammatory cytokines implicated in myocardial dysfunction. We determined whether TLR-4 was necessary for LPS-induced myocardial dysfunction in vivo. The effects of LPS on left ventricular (LV) function were studied in mice with defective TLR-4 signaling (C3H/HeJ, TLR-4 deficient) and wild-type mice (C3HeB/FeJ). Mice (n = 5/group) were injected with LPS or diluent, and LV function was examined by using two-dimensional echocardiography and conductance catheters. LPS significantly decreased all indexes of LV function in wild-type mice when compared with controls; LV function was not depressed in the LPS-treated TLR-4-deficient mice relative to controls. LPS increased myocardial nitric oxide synthase-2 expression and cGMP only in wild-type mice. This study suggests that TLR-4 mediates the LV dysfunction that occurs in LPS-induced shock. Therefore, TLR-4 might be a therapeutic target for attenuating the effects of LPS on the heart.

innate immunity; endotoxic shock; proinflammatory cytokine; myocardial depression


This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
C. Hall, M. V. Flores, A. Chien, A. Davidson, K. Crosier, and P. Crosier
Transgenic zebrafish reporter lines reveal conserved Toll-like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineages
J. Leukoc. Biol., May 1, 2009; 85(5): 751 - 765.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
T. Peng, T. Zhang, X. Lu, and Q. Feng
JNK1/c-fos inhibits cardiomyocyte TNF-{alpha} expression via a negative crosstalk with ERK and p38 MAPK in endotoxaemia
Cardiovasc Res, March 1, 2009; 81(4): 733 - 741.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W. Chao
Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart
Am J Physiol Heart Circ Physiol, January 1, 2009; 296(1): H1 - H12.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Feng, H. Zhao, X. Xu, E. S. Buys, M. J. Raher, J. C. Bopassa, H. Thibault, M. Scherrer-Crosbie, U. Schmidt, and W. Chao
Innate immune adaptor MyD88 mediates neutrophil recruitment and myocardial injury after ischemia-reperfusion in mice
Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1311 - H1318.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
T. Ha, F. Hua, X. Liu, J. Ma, J. R. McMullen, T. Shioi, S. Izumo, J. Kelley, X. Gao, W. Browder, et al.
Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism
Cardiovasc Res, June 1, 2008; 78(3): 546 - 553.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
A. Riad, S. Bien, M. Gratz, F. Escher, M. M. Heimesaat, S. Bereswill, T. Krieg, S. B. Felix, H. P. Schultheiss, H. K. Kroemer, et al.
Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice
Eur J Heart Fail, March 1, 2008; 10(3): 233 - 243.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Khaleduzzaman, J. Francis, M. E. Corbin, E. McIlwain, M. Boudreaux, M. Du, T. W. Morgan, and K. E. Peterson
Infection of Cardiomyocytes and Induction of Left Ventricle Dysfunction by Neurovirulent Polytropic Murine Retrovirus
J. Virol., November 15, 2007; 81(22): 12307 - 12315.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
X. Zhu, H. Zhao, A. R. Graveline, E. S. Buys, U. Schmidt, K. D. Bloch, A. Rosenzweig, and W. Chao
MyD88 and NOS2 are essential for Toll-like receptor 4-mediated survival effect in cardiomyocytes
Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1900 - H1909.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Ha, F. Hua, D. Grant, Y. Xia, J. Ma, X. Gao, J. Kelley, D. L. Williams, J. Kalbfleisch, I. W. Browder, et al.
Glucan phosphate attenuates cardiac dysfunction and inhibits cardiac MIF expression and apoptosis in septic mice
Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1910 - H1918.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T. M. El-Achkar, X. Huang, Z. Plotkin, R. M. Sandoval, G. J. Rhodes, and P. C. Dagher
Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney
Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1034 - F1043.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. Tao, V. T. Enoh, C. Y. Lin, W. E. Johnston, P. Li, and E. R. Sherwood
Cardiovascular dysfunction caused by cecal ligation and puncture is attenuated in CD8 knockout mice treated with anti-asialoGM1
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R478 - R485.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. G. Vallejo, S. Nemoto, M. Ishiyama, B. Yu, P. Knuefermann, A. Diwan, J. S. Baker, G. Defreitas, D. J. Tweardy, and D. L. Mann
Functional significance of inflammatory mediators in a murine model of resuscitated hemorrhagic shock
Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1272 - H1277.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
X. Meng, L. Ao, Y. Song, C. D. Raeburn, D. A. Fullerton, and A. H. Harken
Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-{alpha} receptor
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2005; 288(3): R600 - R606.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. W. Binck, M. F. Tsen, M. Islas, D. J. White, R. A. Schultz, M. S. Willis, J. V. Garcia, J. W. Horton, and J. A. Thomas
Bone marrow-derived cells contribute to contractile dysfunction in endotoxic shock
Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H577 - H583.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. Knuefermann, Y. Sakata, J. S. Baker, C.-H. Huang, K. Sekiguchi, H. S. Hardarson, O. Takeuchi, S. Akira, and J. G. Vallejo
Toll-Like Receptor 2 Mediates Staphylococcus aureus-Induced Myocardial Dysfunction and Cytokine Production in the Heart
Circulation, December 14, 2004; 110(24): 3693 - 3698.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
N. Nozaki, T. Shishido, Y. Takeishi, and I. Kubota
Modulation of Doxorubicin-Induced Cardiac Dysfunction in Toll-Like Receptor-2-Knockout Mice
Circulation, November 2, 2004; 110(18): 2869 - 2874.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. Tao and E. R. Sherwood
{beta}2-Microglobulin knockout mice treated with anti-asialoGM1 exhibit improved hemodynamics and cardiac contractile function during acute intra-abdominal sepsis
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2004; 286(3): R569 - R575.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J.-i. Oyama, C. Blais Jr, X. Liu, M. Pu, L. Kobzik, R. A. Kelly, and T. Bourcier
Reduced Myocardial Ischemia-Reperfusion Injury in Toll-Like Receptor 4-Deficient Mice
Circulation, February 17, 2004; 109(6): 784 - 789.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
C. Li, T. Ha, J. Kelley, X. Gao, Y. Qiu, R. L Kao, W. Browder, and D. L Williams
Modulating Toll-like receptor mediated signaling by (1->3)-{beta}-D-glucan rapidly induces cardioprotection
Cardiovasc Res, February 15, 2004; 61(3): 538 - 547.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
D. de Kleijn and G. Pasterkamp
Toll-like receptors in cardiovascular diseases
Cardiovasc Res, October 15, 2003; 60(1): 58 - 67.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
W. C. Levy and I. B. Hirsch
Diabetes and heart failure: is insulin therapy the answer?
J. Am. Coll. Cardiol., September 17, 2003; 42(6): 1051 - 1053.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. A. Thomas, S. B. Haudek, T. Koroglu, M. F. Tsen, D. D. Bryant, D. J. White, D. F. Kusewitt, J. W. Horton, and B. P. Giroir
IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction
Am J Physiol Heart Circ Physiol, August 1, 2003; 285(2): H597 - H606.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Peng, X. Lu, M. Lei, and Q. Feng
Endothelial Nitric-oxide Synthase Enhances Lipopolysaccharide-stimulated Tumor Necrosis Factor-alpha Expression via cAMP-mediated p38 MAPK Pathway in Cardiomyocytes
J. Biol. Chem., February 28, 2003; 278(10): 8099 - 8105.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. Knuefermann, S. Nemoto, A. Misra, N. Nozaki, G. Defreitas, S. M. Goyert, B. A. Carabello, D. L. Mann, and J. G. Vallejo
CD14-Deficient Mice Are Protected Against Lipopolysaccharide-Induced Cardiac Inflammation and Left Ventricular Dysfunction
Circulation, November 12, 2002; 106(20): 2608 - 2615.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online