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Department of Cardiological Sciences, St. George's Hospital Medical School, London SW17 0RE, United Kingdom
Recently, it was demonstrated that the
QT-RR relationship pattern varies significantly among healthy
individuals. We compared the intra- and interindividual variations of
the QT-RR relationship. Twenty-four-hour 12-lead digital
electrocardiograms (ECGs; SEER MC, GE Marquette; 10-s ECG recorded
every 30 s) were obtained at baseline and after 24 h, 1 wk,
and 1 mo in 75 healthy subjects (42 women, 33 men, age 27.9 ± 9.6 vs. 26.8 ± 7.5 yr, P = not significant). QT
interval was measured automatically in each ECG by six different algorithms, and the mean of the six measurements was analyzed. In each
recording of each individual, QT-RR relationship was assessed by 10 different regression models including linear (QT = 
+ 
× RR) and parabolic (QT = × RR
)
models. Standard deviations (SDs) of regression parameters and of consecutive recordings of each individual were compared with SD of
the individual means. Intrasubject stability and interindividual variability were further tested by ANOVA. With all models,
intraindividual SDs of the regression parameters were highly
significantly smaller than SD of individual means (P < 10
5-109). The intrasubject stability
was further confirmed by ANOVA (P < 1019-1030). The QT-RR relationship
exhibits substantial intersubject variability as well as a high
intrasubject stability. This has practical implications for a precise
estimation of the heart rate-corrected QT interval in which optimized
subject-specific rate correction formulas should be used.
corrected QT interval; repolarization
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