| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-adrenoceptors mediate migration of vascular
smooth muscle cells and adventitial fibroblasts in vitro
Departments of 1 Cell and Molecular Physiology and 2 Orthopedics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599
Norepinephrine directly induces growth of
the vascular wall, which may involve not only proliferation of smooth
muscle cells (SMCs) and adventitial fibroblasts (AFBs) but also
augmentation of their migration. To test this hypothesis,
growth-arrested SMCs and AFBs from rat aorta were exposed to
norepinephrine. Norepinephrine caused dose-dependent migration of both
cell types that was dependent on chemotaxis. In contrast,
platelet-derived growth factor (PDGF)-BB, used as a positive control,
stimulated both chemotaxis and chemokinesis. Only
1D-adrenoceptors (AR) and 2-AR
antagonists inhibited norepinephrine migration of SMCs, whereas
norepinephrine migration of AFBs was only inhibited by
1A-AR and 1B-AR antagonists; 
-AR
blockade was without effect. Norepinephrine and PDGF-BB were additive
for AFB, but not SMC, migration. Stimulation of migration was reversed at high norepinephrine concentrations (10 µM); this inhibition was
mediated by 2- and -ARs in AFBs but not in SMCs. Thus
norepinephrine induces migration of SMCs and AFBs via different
-ARs. This action may participate in wall remodeling and
norepinephrine potentiation of injury-induced intimal lesion growth.
artery; adrenergic receptor; growth; remodeling; platelet-derived growth factor
This article has been cited by other articles:
|
|
 |
|
  M. C. Vinci, L. Bellik, S. Filippi, F. Ledda, and A. Parenti Trophic effects induced by {alpha}1D-adrenoceptors on endothelial cells are potentiated by hypoxia Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2140 - H2147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Faber, C. L. Szymeczek, S. Cotecchia, S. A. Thomas, A. Tanoue, G. Tsujimoto, and H. Zhang {alpha}1-Adrenoceptor-dependent vascular hypertrophy and remodeling in murine hypoxic pulmonary hypertension Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2316 - H2323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Faber, C. L. Szymeczek, S. S. Salvi, and H. Zhang Enhanced {alpha}1-adrenergic trophic activity in pulmonary artery of hypoxic pulmonary hypertensive rats Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2272 - H2281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Erami, H. Zhang, A. Tanoue, G. Tsujimoto, S. A. Thomas, and J. E. Faber Adrenergic catecholamine trophic activity contributes to flow-mediated arterial remodeling Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H744 - H753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chalothorn, H. Zhang, J. A. Clayton, S. A. Thomas, and J. E. Faber Catecholamines augment collateral vessel growth and angiogenesis in hindlimb ischemia Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H947 - H959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C McGrath, C. Deighan, A. M Briones, M. M. Shafaroudi, M. McBride, J. Adler, S. M Arribas, E. Vila, and C. J Daly New aspects of vascular remodelling: the involvement of all vascular cell types Exp Physiol, July 1, 2005; 90(4): 469 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhang, D. Chalothorn, L. F. Jackson, D. C. Lee, and J. E. Faber Transactivation of Epidermal Growth Factor Receptor Mediates Catecholamine-Induced Growth of Vascular Smooth Muscle Circ. Res., November 12, 2004; 95(10): 989 - 997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang, S. Cotecchia, S. A. Thomas, A. Tanoue, G. Tsujimoto, and J. E. Faber Gene deletion of dopamine {beta}-hydroxylase and {alpha}1-adrenoceptors demonstrates involvement of catecholamines in vascular remodeling Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2106 - H2114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Wall, J. E. Faber, X. Yang, M. Tsuzaki, and A. J. Banes Norepinephrine-induced calcium signaling and expression of adrenoceptors in avian tendon cells Am J Physiol Cell Physiol, October 1, 2004; 287(4): C912 - C918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Bleeke, H. Zhang, N. Madamanchi, C. Patterson, and J. E. Faber Catecholamine-Induced Vascular Wall Growth Is Dependent on Generation of Reactive Oxygen Species Circ. Res., January 9, 2004; 94(1): 37 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Teeters, C. Erami, H. Zhang, and J. E. Faber Systemic alpha 1A-adrenoceptor antagonist inhibits neointimal growth after balloon injury of rat carotid artery Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H385 - H392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Erami, H. Zhang, J. G. Ho, D. M. French, and J. E. Faber alpha 1-Adrenoceptor stimulation directly induces growth of vascular wall in vivo Am J Physiol Heart Circ Physiol, October 1, 2002; 283(4): H1577 - H1587. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
