AJP - Heart Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 282: H2406-H2413, 2002. First published January 24, 2002; doi:10.1152/ajpheart.00320.2001
0363-6135/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/6/H2406    most recent
00320.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (14)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bassani, R. A.
Right arrow Articles by Bassani, J. W. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bassani, R. A.
Right arrow Articles by Bassani, J. W. M.
Vol. 282, Issue 6, H2406-H2413, June 2002

Contribution of Ca2+ transporters to relaxation in intact ventricular myocytes from developing rats

Rosana A. Bassani and José W. M. Bassani

Centro de Engenharia Biomédica and Departamento de Engenharia Biomédica/ Faculdade de Engenharia Elétrica e de Computação, Universidade Estadual de Campinas, Campinas 13083-971, Brazil

The relative contributions of Ca2+ transporters to intracellular Ca2+ concentration ([Ca2+]i) decline associated with twitch relaxation were analyzed in intact ventricular myocytes from developing and adult rats. This was accomplished by estimation of individual integrated Ca2+ fluxes with the use of kinetic parameters calculated from [Ca2+]i measurements during twitches and caffeine-evoked contractures, and from myocardial passive Ca2+ buffering data. Our main findings were the following: 1) twitch relaxation and [Ca2+]i decline were significantly slower during the first postnatal week than in adults, 2) inhibition of sarcoplasmic reticulum (SR) Ca2+ accumulation resulted in faster [Ca2+]i decline in young cells than in adult cells, 3) the contributions of the SR Ca2+ uptake and Na+/Ca2+ exchange (NCX) to twitch relaxation increased from ~75 to 92%, and decreased from 24 to 5%, respectively, from birth to adulthood, and 4) Ca2+ transport by the sarcolemmal Ca2+-ATPase was apparently increased in neonates. Our data indicate that despite a marked increase in NCX contribution to cell relaxation in immature rats, the SR Ca2+-ATPase appears to be the predominant transporter responsible for relaxation-associated [Ca2+]i decline from birth to adulthood.

sarcoplasmic reticulum Ca2+-ATPase; Na+-Ca2+ exchange; sarcolemmal Ca2+-ATPase; mitochondrial Ca2+ uniporter


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
A. Guo and H.-T. Yang
Ca2+ removal mechanisms in mouse embryonic stem cell-derived cardiomyocytes
Am J Physiol Cell Physiol, January 1, 2009; 297(3): C732 - C741.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. J. Wang and E. A. Sobie
Mathematical model of the neonatal mouse ventricular action potential
Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2565 - H2575.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. Huang, L. Hove-Madsen, and G. F. Tibbits
SR Ca2+ refilling upon depletion and SR Ca2+ uptake rates during development in rabbit ventricular myocytes
Am J Physiol Cell Physiol, December 1, 2007; 293(6): C1906 - C1915.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. M. R. Carvalho, R. A. Bassani, K. G. Franchini, and J. W. M. Bassani
Enhanced calcium mobilization in rat ventricular myocytes during the onset of pressure overload-induced hypertrophy
Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1803 - H1813.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. Huang, L. Hove-Madsen, and G. F. Tibbits
Na+/Ca2+ exchange activity in neonatal rabbit ventricular myocytes
Am J Physiol Cell Physiol, January 1, 2005; 288(1): C195 - C203.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online