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Am J Physiol Heart Circ Physiol 283: H118-H125, 2002. First published March 21, 2002; doi:10.1152/ajpheart.00690.2001
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Vol. 283, Issue 1, H118-H125, July 2002

Myogenic response of rat femoral small arteries in relation to wall structure and [Ca2+]i

Vladimir V. Matchkov1, Olga S. Tarasova3, Michael J. Mulvany2, and Holger Nilsson1

1 Department of Physiology and 2 Department of Pharmacology, University of Aarhus, DK-8000 Aarhus C, Denmark; and 3 Department of Human and Animal Physiology, Moscow State University, Moscow, RU-119899, Russia

The present study investigated the influence of media thickness on myogenic tone and intracellular calcium concentration ([Ca2+]i) in rat skeletal muscle small arteries. A ligature was loosely tied around one external iliac artery of 5-wk-old spontaneously hypertensive rats. At 18 wk of age, femoral artery blood pressure was 102 ± 11 mmHg (n = 15) on the ligated side and 164 ± 6 mmHg (n = 15) on the contralateral side. Small arteries feeding the gracilis muscle had a reduced media cross-sectional area and a reduced media-to-lumen ratio on the ligated side, where also the range of myogenic constriction was shifted to lower pressures. However, when expressed as a function of wall stress, diameter responses were nearly identical. [Ca2+]i was higher in vessels from the ligated hindlimb at pressures above 10 mmHg, but vasoconstriction was not accompanied by changes in [Ca2+]i. Thus the myogenic constriction here seems due primarily to changes in intracellular calcium sensitivity, which are determined mainly by the force per cross-sectional area of the wall and therefore altered by changes in vascular structure.

intracellular calcium concentration; endothelium; fura 2; Ca-channel antagonists


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