AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 283: H302-H314, 2002. First published March 7, 2002; doi:10.1152/ajpheart.00044.2002
0363-6135/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/1/H302    most recent
00044.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (17)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Xu, Y.
Right arrow Articles by Chiamvimonvat, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xu, Y.
Right arrow Articles by Chiamvimonvat, N.
Vol. 283, Issue 1, H302-H314, July 2002

Presence of a calcium-activated chloride current in mouse ventricular myocytes

Yanfang Xu1, Pei Hong Dong2, Zhao Zhang1, Gias Uddin Ahmmed2, and Nipavan Chiamvimonvat1

1 Division of Cardiovascular Medicine, Department of Medicine, University of California, Davis, California 95616; and 2 Division of Cardiology, University of Cincinnati, Cincinnati, Ohio 44267

The properties of several components of outward K+ currents, including the pharmacological and kinetics profiles as well as the respective molecular correlates, have been identified in mouse cardiac myocytes. Surprisingly little is known with regard to the Ca2+-activated ionic currents. We studied the Ca2+-activated transient outward currents in mouse ventricular myocytes. We have identified a 4-aminopyridine (4-AP)- and tetraethyl ammonium-resistant transient outward current that is Ca2+ dependent. The current is carried by Cl- and is critically dependent on Ca2+ influx via voltage-gated Ca2+ channels and the sarcoplasmic reticulum Ca2+ store. The current can be blocked by the anion transport blockers niflumic acid and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid. Single channel recordings reveal small conductance channels (~1 pS in 140 mM Cl-) that can be blocked by anion transport blockers. Ensemble-averaged current faithfully mirrors the transient kinetics observed at the whole level. Niflumic acid (in the presence of 4-AP) leads to prolongation of the early repolarization. Thus this current may contribute to early repolarization of action potentials in mouse ventricular myocytes.

cardiac


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
C. Pott, X. Ren, D. X. Tran, M.-J. Yang, S. Henderson, M. C. Jordan, K. P. Roos, A. Garfinkel, K. D. Philipson, and J. I. Goldhaber
Mechanism of shortened action potential duration in Na+-Ca2+ exchanger knockout mice
Am J Physiol Cell Physiol, February 1, 2007; 292(2): C968 - C973.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Yamamoto and T. Ehara
Acidic extracellular pH-activated outwardly rectifying chloride current in mammalian cardiac myocytes
Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H1905 - H1914.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. Tuteja, D. Xu, V. Timofeyev, L. Lu, D. Sharma, Z. Zhang, Y. Xu, L. Nie, A. E Vazquez, J. N. Young, et al.
Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes
Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2714 - H2723.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G.-L. Wang, G.-X. Wang, S. Yamamoto, L. Ye, H. Baxter, J. R Hume, and D. Duan
Molecular mechanisms of regulation of fast-inactivating voltage-dependent transient outward K+ current in mouse heart by cell volume changes
J. Physiol., October 15, 2005; 568(2): 423 - 443.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
Z. Zhang, Y. He, D. Tuteja, D. Xu, V. Timofeyev, Q. Zhang, K. A. Glatter, Y. Xu, H.-S. Shin, R. Low, et al.
Functional Roles of Cav1.3({alpha}1D) Calcium Channels in Atria: Insights Gained From Gene-Targeted Null Mutant Mice
Circulation, September 27, 2005; 112(13): 1936 - 1944.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. Huang, L. Hove-Madsen, and G. F. Tibbits
Na+/Ca2+ exchange activity in neonatal rabbit ventricular myocytes
Am J Physiol Cell Physiol, January 1, 2005; 288(1): C195 - C203.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
V. E. Bondarenko, G. P. Szigeti, G. C. L. Bett, S.-J. Kim, and R. L. Rasmusson
Computer model of action potential of mouse ventricular myocytes
Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1378 - H1403.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
F. Brette, J.-Y. Le Guennec, and I. Findlay
Low-voltage triggering of Ca2+ release from the sarcoplasmic reticulum in cardiac muscle cells
Am J Physiol Cell Physiol, December 1, 2003; 285(6): C1544 - C1552.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
F. Brette, A. Lacampagne, L. Salle, I. Findlay, and J.-Y. Le Guennec
Intracellular Cs+ activates the PKA pathway, revealing a fast, reversible, Ca2+-dependent inactivation of L-type Ca2+ current
Am J Physiol Cell Physiol, August 1, 2003; 285(2): C310 - C318.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online