AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 283: H38-H43, 2002. First published February 14, 2002; doi:10.1152/ajpheart.00866.2001
0363-6135/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/1/H38    most recent
00866.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tissier, R.
Right arrow Articles by Ghaleh, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tissier, R.
Right arrow Articles by Ghaleh, B.
Vol. 283, Issue 1, H38-H43, July 2002

Adenosine A1-receptor induced late preconditioning and myocardial infarction: reperfusion duration is critical

Renaud Tissier1, Rachid Souktani1, Patrick Bruneval2, Jean-François Giudicelli1, Alain Berdeaux1, and Bijan Ghaleh1

1 Département de Pharmacologie, Faculté de Médecine Paris Sud and Institut National de la Santé et de la Recherche Médicale (INSERM) E00.01, 94276 Le Kremlin-Bicêtre Cedex, France; and 2 INSERM U430, Hôpital Broussais, 75014 Paris, France

We investigated the influence of coronary artery reperfusion (CAR) duration on the infarct-limiting properties of adenosine A1-receptor stimulation-induced delayed preconditioning (A1-DPC) compared with ischemia-induced delayed preconditioning (I-DPC). Sixty-one chronically instrumented conscious rabbits successfully underwent the following protocol. On day 1, rabbits were randomly divided into four groups: control (saline, iv), I-DPC (six 4-min coronary artery occlusion/4-min reperfusion cycles), A1-DPC100 (N6-cyclopentyladenosine, 100 µg/kg iv), and A1-DPC400 (N6-cyclopentyladenosine, 400 µg/kg iv). On day 2 (i.e., 24 h later), rabbits underwent a 30-min coronary artery occlusion after which CAR was started and maintained for either 3 or 72 h. Infarct size (percentage of the area at risk) was determined by triphenyltetrazolium chloride staining. After 3 h of CAR, I-DPC, A1-DPC100, and A1-DPC400 significantly decreased infarct size (36 ± 5, 41 ± 4, 38 ± 5%, respectively) compared with control (55 ± 3%). After 72 h of CAR, infarct sizes were not significantly different among the four groups. This result was confirmed by histologic analysis. Thus A1-DPC at the two investigated doses, as well as I-DPC, decreased infarct size after 3 h but not 72 h of CAR.

ischemia; cardioprotection; N6-cyclopentyladenosine; infarct size


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. Aouam, R. Tissier, P. Bruneval, C. Mandet, A. Berdeaux, and B. Ghaleh
Preconditioning of salvaged myocardium in conscious rabbits with postinfarction dysfunction
Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2763 - H2769.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. Kristo, Y. Yoshimura, B. J. Keith, R. M. Stevens, S. A. Jahania, R. M. Mentzer Jr., and R. D. Lasley
Adenosine A1/A2a receptor agonist AMP-579 induces acute and delayed preconditioning against in vivo myocardial stunning
Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2746 - H2753.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online