AJP - Heart Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 283: H540-H548, 2002. First published April 18, 2002; doi:10.1152/ajpheart.00032.2002
0363-6135/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/2/H540    most recent
00032.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leary, S. C.
Right arrow Articles by Moyes, C. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leary, S. C.
Right arrow Articles by Moyes, C. D.
Vol. 283, Issue 2, H540-H548, August 2002

Bioenergetic remodeling of heart during treatment of spontaneously hypertensive rats with enalapril

S. C. Leary1, D. Michaud1, C. N. Lyons1, T. M. Hale2, T. L. Bushfield2, M. A. Adams2, and C. D. Moyes1

Departments of 1 Biology and 2 Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada K7L 3N6

We used spontaneously hypertensive rats to study remodeling of cardiac bioenergetics associated with changes in blood pressure. Blood pressure was manipulated with aggressive antihypertensive treatment combining low dietary salt and the angiotensin-converting enzyme inhibitor enalapril. Successive cycles of 2 wk on, 2 wk off treatment led to rapid, reversible changes in left ventricular (LV) mass (30% change in <10 days). Despite changes in LV mass, specific activities of bioenergetic (cytochrome-c oxidase, citrate synthase, lactate dehydrogenase) and reactive oxygen species (ROS) (total cellular superoxide dismutase) enzymes were actively maintained within relatively narrow ranges regardless of treatment duration, organismal age, or transmural region. Although enalapril led to parallel declines in mitochondrial enzyme content and ventricular mass, total ventricular mtDNA content was unaffected. Altered enzymatic content occurred without significant changes in relevant mRNA and protein levels. Transcript levels of gene products involved in mtDNA maintenance (Tfam), mitochondrial protein degradation (LON protease), fusion (fuzzy onion homolog), and fission (dynamin-like protein, synaptojanin-2alpha ) were also unchanged. In contrast, enalapril-mediated ventricular and mitochondrial remodeling was accompanied by a twofold increase in specific activity of catalase, an indicator of oxidative stress, suggesting that rapid cardiac adaptation is accompanied by tight regulation of mitochondrial enzyme activities and increased ROS production.

hypertension; mitochondria; mitochondrial deoxyribonucleic acid; angiotensin-converting enzyme inhibitor; spontaneously hypertensive rats; cytochrome oxidase; oxidative stress


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
N. G. Abraham, J. Cao, D. Sacerdoti, X. Li, and G. Drummond
Heme oxygenase: the key to renal function regulation
Am J Physiol Renal Physiol, November 1, 2009; 297(5): F1137 - F1152.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M.-C. Battista, E. Calvo, A. Chorvatova, B. Comte, J. Corbeil, and M. Brochu
Intra-uterine growth restriction and the programming of left ventricular remodelling in female rats
J. Physiol., May 15, 2005; 565(1): 197 - 205.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. C. Dalziel, S. E. Moore, and C. D. Moyes
Mitochondrial enzyme content in the muscles of high-performance fish: evolution and variation among fiber types
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R163 - R172.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Benderdour, G. Charron, B. Comte, R. Ayoub, D. Beaudry, S. Foisy, D. deBlois, and C. Des Rosiers
Decreased cardiac mitochondrial NADP+-isocitrate dehydrogenase activity and expression: a marker of oxidative stress in hypertrophy development
Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2122 - H2131.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
A. Bosy-Westphal, C. Eichhorn, D. Kutzner, K. Illner, M. Heller, and M. J. Muller
The Age-Related Decline in Resting Energy Expenditure in Humans Is Due to the Loss of Fat-Free Mass and to Alterations in Its Metabolically Active Components
J. Nutr., July 1, 2003; 133(7): 2356 - 2362.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online