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Am J Physiol Heart Circ Physiol 283: H650-H657, 2002; doi:10.1152/ajpheart.00043.2002
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Vol. 283, Issue 2, H650-H657, August 2002

Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction

Christopher D. Raeburn, Charles A. Dinarello, Michael A. Zimmerman, Casey M. Calkins, Benjamin J. Pomerantz, Robert C. McIntyre Jr., Alden H. Harken, and Xianzhong Meng

Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262

Tumor necrosis factor-alpha (TNF-alpha ) and interleukin-1beta (IL-1beta ) have been implicated in cardiac dysfunction during endotoxemia. Because IL-18 is a proinflammatory cytokine known to mediate the production of TNF-alpha and IL-1beta and to induce the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), we hypothesized that neutralization of IL-18 would attenuate lipopolysaccharide (LPS)-induced cardiac dysfunction. Mice (C57BL/6) were injected with LPS (0.5 mg/kg ip) or vehicle (normal saline), and left ventricular developed pressure (LVDP) was determined by the Langendorff technique. LVDP was depressed by 38% at 6 h after LPS. LPS-induced myocardial dysfunction was associated with increased myocardial levels of TNF-alpha and IL-1beta as well as increased expression of ICAM-1/VCAM-1. Pretreatment with neutralizing anti-mouse IL-18 antibody attenuated LPS-induced myocardial dysfunction (by 92%) and was associated with reduced myocardial IL-1beta production (65% reduction) and ICAM-1/VCAM-1 expression (50% and 35% reduction, respectively). However, myocardial TNF-alpha levels were not influenced by neutralization of IL-18. In conclusion, neutralization of IL-18 protects against LPS-induced myocardial dysfunction. IL-18 may mediate endotoxemic myocardial dysfunction through induction of and/or synergy with IL-1beta , ICAM-1, and VCAM-1.

tumor necrosis factor-alpha ; interleukin-18


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