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Am J Physiol Heart Circ Physiol 283: H1181-H1190, 2002. First published May 23, 2002; doi:10.1152/ajpheart.00187.2002
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Vol. 283, Issue 3, H1181-H1190, September 2002

A new inbred Wistar-Kyoto rat substrain exhibiting apparent salt sensitivity and borderline hypertension

Adamu Alemayehu, Laura Breen, and Morton P. Printz

Department of Pharmacology, University of California San Diego, La Jolla, California 92093-0636

The normotensive Wistar-Kyoto (WKY) rat strain is a traditional control for the spontaneously hypertensive rat (SHR). We found trait differences between two inbred normotensive WKY strains, derived originally from different vendors, and compared these two strains from La Jolla-Taconic Farms (WKY/lj-tf) and La Jolla-Charles River (WKY/lj-cr) with the inbred SHR/lj-cr for cardiovascular, diurnal, and activity traits under normal and high (8%) NaCl diets. Marked genetic diversity was found between the two vendor-derived WKY. By using an extended study design and radiotelemetry, we compared WKY/lj-cr, WKY/lj-tf, and SHR/lj-cr with the following results: systolic pressure (120 ± 1, 133 ± 1, 168 ± 3 mmHg, respectively); diurnal variation in heart rate (Delta HR: 46 ± 3, 71 ± 4, 57 ± 2 beats/min, respectively); and salt sensitivity of arterial pressure (Delta systolic: 10 ± 1, 21 ± 1, 20 ± 1 mmHg, respectively). The WKY/lj-tf genotype apparently results in compromised control of arterial pressure and heart rate, especially during high NaCl intake, and greater susceptibility to high pressure (i.e., high NaCl-induced secondary changes). WKY/lj-tf thus constitutes a new inbred borderline hypertensive WKY substrain offering unique opportunities for genomic studies into the development of genetic hypertension.

inbred strains; hypertension sodium-dependent; genotype; circadian rhythm; radiotelemetry; heart rate; polymorphism


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