| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Cardiovascular Medicine and 2 Department of Pharmacology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638; and 3 Laboratory of Anatomy, Hokkaido University Graduate School of Veterinary Medicine, Sapporo 060-0818, Japan
With the use of Otsuka Long-Evans
Tokushima Fatty (OLETF) rats, a model of human non-insulin-dependent
diabetes mellitus (NIDDM), we assessed whether ANG II is involved in
coronary capillary angiogenesis at the insulin-resistant stage of NIDDM
(20 wk of age). In OLETF rats, ANG II labeling and angiotensin type 1 (AT1) receptor expression in coronary vessels were
increased more than in nondiabetic controls. A marked increase in
vascular expression of vascular endothelial growth factor (VEGF) at
both mRNA and protein levels was found in OLETF rats. The increased
expression level of VEGF was associated with accumulation of
hypoxia-inducible factor-1
(HIF-1) activated by increased
advanced glycation end products (AGEs). Morphometric analysis showed a
significantly increased total coronary capillary density, which was a
result of arterialization of the venular capillary portion in OLETF
rats. Treatment of OLETF rats with candesartan, an AT1
receptor blocker, inhibited vascular expressions of VEGF, HIF-1, and
AGEs, and ameliorated the morphometric changes. These results suggest a
key role of ANG II in the pathogenesis of the coronary capillary
remodeling in this NIDDM model.
vascular endothelial growth factor; hypoxia-inducible factor-1; advanced glycation end products; coronary capillary remodeling; angiotensin II; non-insulin-dependent diabetes mellitus
This article has been cited by other articles:
|
|
 |
|
  K. Rakusan, Z. Chvojkova, P. Oliviero, I. Ostadalova, F. Kolar, C. Chassagne, J.-L. Samuel, and B. Ostadal ANG II type 1 receptor antagonist irbesartan inhibits coronary angiogenesis stimulated by chronic intermittent hypoxia in neonatal rats Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1237 - H1244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Iemitsu, S. Maeda, S. Jesmin, T. Otsuki, and T. Miyauchi Exercise training improves aging-induced downregulation of VEGF angiogenic signaling cascade in hearts Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1290 - H1298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Iemitsu, S. Maeda, S. Jesmin, T. Otsuki, Y. Kasuya, and T. Miyauchi Activation pattern of MAPK signaling in the hearts of trained and untrained rats following a single bout of exercise J Appl Physiol, July 1, 2006; 101(1): 151 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Jesmin, S. Zaedi, S. Maeda, C. N. Mowa, I. Sakuma, and T. Miyauchi Reversal of Elevated Cardiac Expression of TGF{beta}1 and Endothelin-1 in OLETF Diabetic Rats by Long-Acting Calcium Antagonist. Experimental Biology and Medicine, June 1, 2006; 231(6): 907 - 912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jesmin, Y. Hattori, S. Maeda, S. Zaedi, I. Sakuma, and T. Miyauchi Subdepressor dose of benidipine ameliorates diabetic cardiac remodeling accompanied by normalization of upregulated endothelin system in rats Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H2146 - H2154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yu, K. Ohmori, Y. Chen, C. Sato, H. Kiyomoto, K. Shinomiya, H. Takeuchi, K. Mizushige, and M. Kohno Effects of pravastatin on progression of glucose intolerance and cardiovascular remodeling in a type II diabetes model J. Am. Coll. Cardiol., August 18, 2004; 44(4): 904 - 913. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
