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Am J Physiol Heart Circ Physiol 283: H1588-H1599, 2002; doi:10.1152/ajpheart.00897.2001
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Vol. 283, Issue 4, H1588-H1599, October 2002

Mechanisms mediating regional sympathoactivatory responses to stimulation of NTS A1 adenosine receptors

Tadeusz J. Scislo and Donal S. O'Leary

Department of Physiology, Wayne State University, School of Medicine, Detroit, Michigan 48201

Selective activation of adenosine A1 and A2a receptors in the subpostremal nucleus tractus solitarius (NTS) increases and decreases mean arterial pressure (MAP), respectively, and decreases heart rate (HR). We have previously shown that the decreases in MAP evoked by NTS A2a receptor stimulation were accompanied with differential sympathetic responses in renal (RSNA), lumbar (LSNA), and preganglionic adrenal sympathetic nerve activity (pre-ASNA). Therefore, now we investigated whether stimulation of NTS A1 receptors via unilateral microinjection of N6-cyclopentyladenosine (CPA) elicits differential activation of the same sympathetic outputs in alpha -chloralose-urethane-anesthetized male Sprague-Dawley rats. CPA (0.33-330.0 pmol in 50 nl) evoked dose-dependent increases in MAP, variable decreases in HR, and differential increases in all recorded sympathetic outputs: up-arrow pre-ASNA up-arrow RSNA >=  up-arrow LSNA. Sinoaortic denervation + vagotomy abolished the MAP and LSNA responses, reversed the normal increases in RSNA into decreases, and significantly attenuated increases in pre-ASNA. NTS ionotropic glutamatergic receptor blockade with kynurenate sodium (4.4 nmol/100 nl) reversed the responses in MAP, LSNA, and RSNA and attenuated the responses in pre-ASNA. We conclude that afferent inputs and intact glutamatergic transmission in the NTS are necessary to mediate the pressor and differential sympathoactivatory responses to stimulation of NTS A1 receptors.

nucleus of the solitary tract; purinergic receptors; adrenal sympathetic nerve; renal sympathetic nerve; lumbar sympathetic nerve


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