AJP - Heart BIOPAC complete lab solutions
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 283: H2363-H2370, 2002. First published August 1, 2002; doi:10.1152/ajpheart.00151.2002
0363-6135/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/6/H2363    most recent
00151.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sutliff, R. L.
Right arrow Articles by Lewis, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sutliff, R. L.
Right arrow Articles by Lewis, W.
Vol. 283, Issue 6, H2363-H2370, December 2002

Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide

Roy L. Sutliff1, Sergey Dikalov2, Daiana Weiss2, Jeremy Parker1, Scott Raidel1, Andrea K. Racine1, Rodney Russ1, Chad P. Haase1, W. Robert Taylor2, and William Lewis1

1 Department of Pathology and Laboratory Medicine and 2 Division of Cardiology, Department of Medicine, Emory University, Atlanta, Georgia 30322

Nucleoside reverse transcriptase inhibitors (NRTIs) have been used successfully to reduce acquired immunodeficiency syndrome mortality. However, the use of these compounds is associated with numerous tissue toxicities, including cardiomyopathy. These studies address the effects of NRTIs on vascular function. Functional assays of contraction and relaxation were performed on isolated mouse aorta segments obtained from FVB/n mice exposed to zidovudine (AZT), stavudine, or water for 35 days. AZT and stavudine treatment impaired sensitivity to endothelium-dependent relaxation by acetylcholine. Dihydroethidium staining revealed that AZT treatment was associated with an increase in superoxide levels. Pretreatment of AZT-treated vessels with tiron (1 mM), a free radical scavenger, restored endothelium-dependent relaxation in mice. In cellular preparations, electron spin resonance measurements revealed elevated superoxide in cultured endothelial cells exposed to AZT; elevation was dependent on the length of exposure. These results indicate that NRTIs impair endothelium-dependent relaxation by increasing superoxide levels and suggest that NRTI therapy contributes to cardiovascular complications in acquired immunodeficiency syndrome.

vascular; reactive oxygen species; nitric oxide; zidovudine; stavudine


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. M. Kleinhenz, D. J. Kleinhenz, S. You, J. D. Ritzenthaler, J. M. Hansen, D. R. Archer, R. L. Sutliff, and C. M. Hart
Disruption of endothelial peroxisome proliferator-activated receptor-{gamma} reduces vascular nitric oxide production
Am J Physiol Heart Circ Physiol, November 1, 2009; 297(5): H1647 - H1654.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. K. Grinspoon, C. Grunfeld, D. P. Kotler, J. S. Currier, J. D. Lundgren, M. P. Dube, S. E. Lipshultz, P. Y. Hsue, K. Squires, M. Schambelan, et al.
State of the Science Conference: Initiative to Decrease Cardiovascular Risk and Increase Quality of Care for Patients Living With HIV/AIDS: Executive Summary
Circulation, July 8, 2008; 118(2): 198 - 210.
[Full Text] [PDF]

Home page
 CirculationHome page
M. P. Dube, S. E. Lipshultz, C. J. Fichtenbaum, R. Greenberg, A. D. Schecter, S. D. Fisher, and for Working Group 3
Effects of HIV Infection and Antiretroviral Therapy on the Heart and Vasculature
Circulation, July 8, 2008; 118(2): e36 - e40.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
N. R. Madamanchi and M. S. Runge
Mitochondrial Dysfunction in Atherosclerosis
Circ. Res., March 2, 2007; 100(4): 460 - 473.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. M. Thule, A. G. Campbell, D. J. Kleinhenz, D. E. Olson, J. J. Boutwell, R. L. Sutliff, and C. M. Hart
Hepatic insulin gene therapy prevents deterioration of vascular function and improves adipocytokine profile in STZ-diabetic rats
Am J Physiol Endocrinol Metab, January 1, 2006; 290(1): E114 - E122.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online