AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 283: H2551-H2559, 2002; doi:10.1152/ajpheart.00616.2002
0363-6135/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (15)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gules, I.
Right arrow Articles by Zhang, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gules, I.
Right arrow Articles by Zhang, J. H.
Vol. 283, Issue 6, H2551-H2559, December 2002

Comparison of three rat models of cerebral vasospasm

Ilker Gules1, Motoyoshi Satoh1, Ben R. Clower2, Anil Nanda3, and John H. Zhang1,3

1 Department of Neurosurgery and 2 Department of Anatomy, University of Mississippi Medical Center, Jackson, Mississippi 39216; and 3 Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130

A substantial number of rat models have been used to research subarachnoid hemorrhage-induced cerebral vasospasm; however, controversy exists regarding which method of selection is appropriate for this species. This study was designed to provide extensive information about the three most popular subarachnoid hemorrhage rat models: the endovascular puncture model, the single-hemorrhage model, and the double-hemorrhage model. In this study, the basilar artery and posterior communicating artery were chosen for histopathological examination and morphometric analysis. Both the endovascular puncture model and single-hemorrhage model developed significant degrees of vasospasm, which were less severe when compared with the double-hemorrhage model. The endovascular puncture model and double-hemorrhage model both developed more vasospasms in the posterior communicating artery than in the basilar artery. The endovascular puncture model has a markedly high mortality rate and high variability in bleeding volume. Overall, the present study showed that the double-hemorrhage model in rats is a more suitable tool with which to investigate mechanism and therapeutic approaches because it accurately correlates with the time courses for vasospasm in humans.

vasospasm; rat; models; subarachnoid hemorrhage


This article has been cited by other articles:


Home page
 Vasc MedHome page
D. Zemke, M. U Farooq, A. Mohammed Yahia, and A. Majid
Delayed ischemia after subarachnoid hemorrhage: result of vasospasm alone or a broader vasculopathy?
Vascular Medicine, August 1, 2007; 12(3): 243 - 249.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. Takeuchi, M. Renic, Q. C. Bohman, D. R. Harder, N. Miyata, and R. J. Roman
Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE
Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2203 - H2211.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
S. Park, M. Yamaguchi, C. Zhou, J.W. Calvert, J. Tang, and J. H. Zhang
Neurovascular Protection Reduces Early Brain Injury After Subarachnoid Hemorrhage
Stroke, October 1, 2004; 35(10): 2412 - 2417.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online