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Am J Physiol Heart Circ Physiol 283: H2551-H2559, 2002; doi:10.1152/ajpheart.00616.2002
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Vol. 283, Issue 6, H2551-H2559, December 2002

Comparison of three rat models of cerebral vasospasm

Ilker Gules1, Motoyoshi Satoh1, Ben R. Clower2, Anil Nanda3, and John H. Zhang1,3

1 Department of Neurosurgery and 2 Department of Anatomy, University of Mississippi Medical Center, Jackson, Mississippi 39216; and 3 Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130

A substantial number of rat models have been used to research subarachnoid hemorrhage-induced cerebral vasospasm; however, controversy exists regarding which method of selection is appropriate for this species. This study was designed to provide extensive information about the three most popular subarachnoid hemorrhage rat models: the endovascular puncture model, the single-hemorrhage model, and the double-hemorrhage model. In this study, the basilar artery and posterior communicating artery were chosen for histopathological examination and morphometric analysis. Both the endovascular puncture model and single-hemorrhage model developed significant degrees of vasospasm, which were less severe when compared with the double-hemorrhage model. The endovascular puncture model and double-hemorrhage model both developed more vasospasms in the posterior communicating artery than in the basilar artery. The endovascular puncture model has a markedly high mortality rate and high variability in bleeding volume. Overall, the present study showed that the double-hemorrhage model in rats is a more suitable tool with which to investigate mechanism and therapeutic approaches because it accurately correlates with the time courses for vasospasm in humans.

vasospasm; rat; models; subarachnoid hemorrhage


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