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Am J Physiol Heart Circ Physiol 283: H2575-H2583, 2002. First published August 22, 2002; doi:10.1152/ajpheart.00164.2002
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Vol. 283, Issue 6, H2575-H2583, December 2002

Olfactory bulbectomy attenuates cardiovascular sympathoexcitatory reflexes in rats

Julia A. Moffitt1, Angela J. Grippo1,2, Philip V. Holmes5, and Alan Kim Johnson1,2,3,4

1 The Cardiovascular Center and Departments of 2 Psychology, 3 Pharmacology, and 4 Exercise Science, University of Iowa, Iowa City, Iowa 52242; and 5 Department of Psychology, University of Georgia, Athens, Georgia 30602

Bilateral removal of the olfactory lobes in rats produces a number of behavioral, endocrine, and neurochemical alterations in the brain. Little is known, however, regarding the effects of this treatment on cardiovascular function and autonomic reflexes. Male Sprague-Dawley rats underwent bilateral surgical ablation of the olfactory bulbs (n = 10) or were sham operated (n = 8). After 3 wk of recovery, animals were instrumented with femoral catheters and a lumbar sympathetic nerve recording electrode. After 24 h of recovery, cardiovascular responses to arterial baroreflex manipulation, air jet stress, and smoke exposure were recorded. Olfactory bulbectomized rats demonstrated attenuated sympathoexcitatory responses to hypotension, air jet stress, and smoke exposure, as well as elevated basal blood pressure, compared with sham-operated rats. These data indicate that the integrity of the olfactory bulbs in rats is important for the elicitation of normal cardiovascular and autonomic responses to a number of evocative stimuli.

arterial baroreflex; lumbar sympathetic nervous system activity; air jet stress; smoke exposure; autonomic nervous system; heart rate; arterial blood pressure


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