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1 Division of Cardiology, The Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, Hershey 17033; and 2 Lebanon Veterans Affairs Medical Center, Lebanon, Pennsylvania 17042
We examined
whether ATP stimulation of P2X purinoceptors would raise blood pressure
in decerebrate cats. Femoral arterial injection of the P2X receptor
agonist 
,
-methylene ATP into the blood supply of the triceps
surae muscle induced a dose-dependent increase in arterial blood
pressure. The maximal increase in mean arterial pressure (MAP) evoked
by 0.1, 0.2, and 0.5 mM ,-methylene ATP (0.5 ml/min injection
rate) was 6.2 ± 2.5, 22.5 ± 4.4, and 35.2 ± 3.9 mmHg,
respectively. The P2X receptor antagonist pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid (2 mM ia) attenuated the
increase in MAP elicited by intra-arterial ,-methylene ATP (0.5 mM), whereas the P2Y receptor antagonist reactive blue 2 (2 mM ia) did
not affect the MAP response to ,-methylene ATP. In a second group
of experiments, we tested the hypothesis that ATP acting through P2X
receptors would sensitize muscle afferents and, thereby, augment the
blood pressure response to muscle stretch. Two kilograms of muscle
stretch evoked a 26.5 ± 4.3 mmHg increase in MAP. This MAP
response was enhanced when 2 mM ATP or 0.1 mM ,-methylene ATP
(0.5 ml/min) was arterially infused 10 min before muscle stretch.
Furthermore, this effect of ATP on the pressor response to stretch was
attenuated by 2 mM pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid (P < 0.05) but not by the P1 purinoceptor
antagonist 8-(p-sulfophenyl)-theophylline (2 mM). These data
indicate that activation of ATP-sensitive P2X receptors evokes a
skeletal muscle afferent-mediated pressor response and that ATP at
relatively low doses enhances the muscle pressor response to stretch
via engagement of P2X receptors.
,-methylene ATP; muscle stretch; skeletal muscle; exercise
pressor reflex; arterial blood pressure
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