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Am J Physiol Heart Circ Physiol 284: H116-H121, 2003. First published September 5, 2002; doi:10.1152/ajpheart.00515.2002
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Vol. 284, Issue 1, H116-H121, January 2003

Role of AT2 receptor in the brain in regulation of blood pressure and water intake

Zhen Li1, Masaru Iwai1, Lan Wu1, Tetsuya Shiuchi1, Toyohisa Jinno1,2, Tai-Xing Cui1, and Masatsugu Horiuchi1

1 Department of Medical Biochemistry, Ehime University School of Medicine, Ehime 791-0295; and 2 Department of Geriatric Medicine, Osaka University Medical School, Suita, Osaka 565-0871, Japan

The effects of intracerebroventricular (ICV) injection of angiotensin II (ANG II) on blood pressure and water intake were examined with the use of ANG II receptor-deficient mice. ICV injection of ANG II increased systolic blood pressure in a dose-dependent manner in wild-type (WT) mice and ANG type 2 AT2 receptor null (knockout) (AT2KO) mice; however, this increase was significantly greater in AT2KO mice than in WT mice. The pressor response to a central injection of ANG II in WT mice was inhibited by ICV preinjection of the selective AT1 receptor blocker valsartan but exaggerated by the AT2 receptor blocker PD-123319. ICV injection of ANG II also increased water intake. It was partly but significantly suppressed both in AT2KO and AT1aKO mice. Water intake in AT2/AT1aKO mice did not respond to ICV injection of ANG II. Both valsartan and PD-123319 partly inhibited water intake in WT mice. These results indicate an antagonistic action between central AT1a and AT2 receptors in the regulation of blood pressure, but they act synergistically in the regulation of water intake induced by ANG II.

angiotensin; central nervous system; intracerebroventricle


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