AJP - Heart Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 284: H249-H255, 2003. First published September 26, 2002; doi:10.1152/ajpheart.00742.2002
0363-6135/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/1/H249    most recent
00742.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yashima, M.
Right arrow Articles by Karagueuzian, H. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yashima, M.
Right arrow Articles by Karagueuzian, H. S.
Vol. 284, Issue 1, H249-H255, January 2003

On the mechanism of the probabilistic nature of ventricular defibrillation threshold

Masaaki Yashima, Young-Hoon Kim, Sean Armin, Tsu-Juey Wu, Yasushi Miyauchi, William J. Mandel, Peng-Sheng Chen, and Hrayr S. Karagueuzian

Division of Cardiology, Cedars-Sinai Medical Center, Department of Medicine, School of Medicine, University of California, Los Angeles, California 90048

The probabilistic nature of the ventricular defibrillation threshold (DFT) remains poorly understood. We hypothesized that shock outcome is a function of the amount of myocardium in its vulnerable period (VP). The endocardial surface of five isolated, perfused swine right ventricles was mapped with 477 bipolar electrodes during ventricular fibrillation (VF). Shock parameters and VF cycle length were not significantly different in the successful (S; n = 26) and failed (F; n = 26) trials. At the instant of the shock, the number of sites with 45- to 55-ms recovery was significantly smaller in the S trials than the F trials (P < 0.04). No significant difference in the number of sites with recovery intervals outside the 45- to 55-ms range was seen in S and F shocks. Endocardial action potential showed that a recovery time of 45-55 ms corresponded to the VP spanning -15 to -60 mV in 92% of the regenerative action potentials. We conclude that the probabilistic nature of the DFT is related to the amount of myocardium in its VP.

ventricular fibrillation; vulnerable period; action potential


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Huang, K.-A. Cheng, D. J. Dosdall, W. M. Smith, and R. E. Ideker
Role of maximum rate of depolarization in predicting action potential duration during ventricular fibrillation
Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2530 - H2536.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. D. Day, R. N. Doshi, P. Belott, U. Birgersdotter-Green, M. Behboodikhah, P. Ott, K. A. Glatter, S. Tobias, H. Frumin, B. K. Lee, et al.
Inductionless or Limited Shock Testing Is Possible in Most Patients With Implantable Cardioverter- Defibrillators/Cardiac Resynchronization Therapy Defibrillators: Results of the Multicenter ASSURE Study (Arrhythmia Single Shock Defibrillation Threshold Testing Versus Upper Limit of Vulnerability: Risk Reduction Evaluation With Implantable Cardioverter-Defibrillator Implantations)
Circulation, May 8, 2007; 115(18): 2382 - 2389.
[Abstract] [Full Text] [PDF]

Home page
 Mayo Clin Proc.Home page
R. D. White
2005 American Heart Association Guidelines for Cardiopulmonary Resuscitation: Physiologic and Educational Rationale for Changes
Mayo Clin. Proc., June 1, 2006; 81(6): 736 - 740.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online