AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 284: H350-H357, 2003. First published September 12, 2002; doi:10.1152/ajpheart.00444.2002
0363-6135/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/1/H350    most recent
00444.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (6)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maniar, H. S.
Right arrow Articles by Moon, M. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maniar, H. S.
Right arrow Articles by Moon, M. R.
Vol. 284, Issue 1, H350-H357, January 2003

Impact of pericardial restraint on right atrial mechanics during acute right ventricular pressure load

Hersh S. Maniar1, Sunil M. Prasad1, Sydney L. Gaynor1, Celeste M. Chu1, Paul Steendijk2, and Marc R. Moon1

1 Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, Missouri; and 2 Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands

Optimization of right atrial (RA) mechanics is important for maintaining right ventricular (RV) filling and global cardiac output. However, the impact of pericardial restraint on RA function and the compensatory role of the right atrium to changes in RV afterload remain poorly characterized. In eight open-chest sheep, RA elastance (contractility) and chamber stiffness were measured (RA pressure-volume relations) at baseline and during partial pulmonary artery (PA) occlusion. Data were collected before and after pericardiotomy. With the pericardium intact and partial PA occlusion, RA elastance increased by 28% (P < 0.04), whereas RA stiffness tended to rise (P = 0.08). However, after pericardiotomy, there was a significant fall in both RA elastance (54%, P < 0.04) and stiffness (39%, P < 0.04), and subsequent PA occlusion failed to induce a change in elastance (P > 0.19) or stiffness (P > 0.84). After pericardiotomy, RA elastance and stiffness fell dramatically, and the compensatory response of the right atrium to elevated RV afterload was lost. The ability of the right atrium to respond to changes in RV hemodynamics is highly dependent on pericardial integrity.

atrial function; conductance catheter; pulmonary artery occlusion


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Zierer, S. J. Melby, R. K. Voeller, and M. R. Moon
Interatrial shunt for chronic pulmonary hypertension: differential impact of low-flow vs. high-flow shunting
Am J Physiol Heart Circ Physiol, March 1, 2009; 296(3): H639 - H644.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Liu, W. Zhang, and G. S. Kassab
Effects of myocardial constraint on the passive mechanical behaviors of the coronary vessel wall
Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H514 - H523.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
K. Kamohara, Z. B. Popovic, M. Daimon, M. Martin, Y. Ootaki, M. Akiyama, F. Zahr, F. Cingoz, C. Ootaki, M. W. Kopcak Jr, et al.
Impact of left atrial appendage exclusion on left atrial function
J. Thorac. Cardiovasc. Surg., January 1, 2007; 133(1): 174 - 181.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. L. Gaynor, H. S. Maniar, J. B. Bloch, P. Steendijk, and M. R. Moon
Right Atrial and Ventricular Adaptation to Chronic Right Ventricular Pressure Overload
Circulation, August 30, 2005; 112(9_suppl): I-212 - I-218.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. L. Gaynor, H. S. Maniar, S. M. Prasad, P. Steendijk, and M. R. Moon
Reservoir and conduit function of right atrium: impact on right ventricular filling and cardiac output
Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2140 - H2145.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online