| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1; and 2 Molecular Cardiovascular Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229
Echocardiograms have been assessed only at 56 days in mice overexpressing calcineurin (CN mice). Age-dependent echocardiographic changes were evaluated because the development of sudden death is time dependent. Because cyclosporin A (CsA) reverses hypertrophy in CN mice, its effects on the time course of the development of sudden death and cardiac dysfunction were assessed. In wild-type (WT) mice, the left ventricular (LV) internal end-diastolic dimension (LVIDd) increased and the LV mass index (LVMI) decreased with age. In CN mice, two distinct phases of pathophysiology were found. After 14 days, in CN mice, the LVIDd and LVMI were significantly increased, but sudden death had not occurred. After 28 days, in CN mice, relative dilation of the left ventricle occurred, whereas the LVMI decreased. Sudden death developed during progressive dilation associated with systolic and diastolic dysfunction. CsA treatment reversed hypertrophy in CN mice but did not reverse systolic and diastolic dysfunction and exaggerated sudden death. Sudden cardiac death was associated with systolic and diastolic dysfunction but was not related to isolated cardiac hypertrophy in CN mice.
heart failure; sudden death; ultrasound; hemodynamics; hypertrophy; left ventricular
This article has been cited by other articles:
|
|
 |
|
  J. Espinoza-Derout, M. Wagner, L. Salciccioli, J. M. Lazar, S. Bhaduri, E. Mascareno, B. Chaqour, and M.A.Q. Siddiqui Positive Transcription Elongation Factor b Activity in Compensatory Myocardial Hypertrophy is Regulated by Cardiac Lineage Protein-1 Circ. Res., June 19, 2009; 104(12): 1347 - 1354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Stypmann, M. A Engelen, C. Troatz, M. Rothenburger, L. Eckardt, and K. Tiemann Echocardiographic assessment of global left ventricular function in mice Lab Anim, April 1, 2009; 43(2): 127 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Somers, P. L. Beck, J. P. Lees-Miller, D. Roach, Y. Li, J. Guo, S. Loken, S. Zhan, L. Semeniuk, and H. J. Duff iNOS in cardiac myocytes plays a critical role in death in a murine model of hypertrophy induced by calcineurin Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1122 - H1131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Pinz, S. E. Ostroy, K. Hoyer, H. Osinska, J. Robbins, J. D. Molkentin, and J. S. Ingwall Calcineurin-induced energy wasting in a transgenic mouse model of heart failure Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1459 - H1466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Zhao, N. H. Jeoung, S. C. Burgess, K. A. Rosaaen-Stowe, T. Inagaki, S. Latif, J. M. Shelton, J. McAnally, R. Bassel-Duby, R. A. Harris, et al. Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H936 - H943. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Suzuki, E. Bayna, H. L. Li, E. D. Molle, and W. Y.W. Lew Lipopolysaccharide Activates Calcineurin in Ventricular Myocytes J. Am. Coll. Cardiol., January 30, 2007; 49(4): 491 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Guo, S. Zhan, J. Somers, R. E. Westenbroek, W. A. Catterall, D. E. Roach, R. S. Sheldon, J. P. Lees-Miller, P. Li, Y. Shimoni, et al. Decrease in density of INa is in the common final pathway to heart block in murine hearts overexpressing calcineurin Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2669 - H2679. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Funakoshi, T. O. Chan, J. C. Good, J. R. Libonati, J. Piuhola, X. Chen, S. M. MacDonnell, L. L. Lee, D. E. Herrmann, J. Zhang, et al. Regulated Overexpression of the A1-Adenosine Receptor in Mice Results in Adverse but Reversible Changes in Cardiac Morphology and Function Circulation, November 21, 2006; 114(21): 2240 - 2250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S.C. Khoo, J. Li, M. V. Singh, Y. Yang, P. Kannankeril, Y. Wu, C. E. Grueter, X. Guan, C. V. Oddis, R. Zhang, et al. Death, Cardiac Dysfunction, and Arrhythmias Are Increased by Calmodulin Kinase II in Calcineurin Cardiomyopathy Circulation, September 26, 2006; 114(13): 1352 - 1359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhang, G. Azhar, M. C. Furr, Y. Zhong, and J. Y. Wei Model of functional cardiac aging: young adult mice with mild overexpression of serum response factor Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2003; 285(3): R552 - R560. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
