| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of 1 Medicine (Molecular Cardiology), 2 Cell Biology, and 5 Pathology, Albert Einstein College of Medicine, Bronx, New York 10461; 3 Division of Cardiovascular Research, St. Elizabeth's Medical Center, Boston, Massachusetts 02135; and 4 Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130
Fas is a widely
expressed cell surface receptor that can initiate apoptosis
when activated by its ligand (FasL). Whereas Fas abundance on cardiac
myocytes increases in response to multiple pathological stimuli, direct
evidence supporting its role in the pathogenesis of heart disease is
lacking. Moreover, controversy exists even as to whether Fas activation
induces apoptosis in cardiac myocytes. In this study, we show
that adenoviral overexpression of FasL, but not 
-galactosidase,
results in marked apoptosis both in cultures of primary
neonatal cardiac myocytes and in the myocardium of intact adult rats.
Myocyte killing by FasL is a specific event, because it does not occur
in lpr (lymphoproliferative) mice that lack functional Fas.
To assess the contribution of the Fas pathway to myocardial infarction
(MI) in vivo, lpr mice were subjected to 30 min of
ischemia followed by 24 h of reperfusion. Compared with
wild-type mice, lpr mice exhibited infarcts that were 62.3%
smaller with 63.8% less myocyte apoptosis. These data provide
direct evidence that activation of Fas can induce apoptosis in
cardiac myocytes and that Fas is a critical mediator of MI due to
ischemia-reperfusion in vivo.
apoptosis; death receptor pathway; genetically altered mice
This article has been cited by other articles:
|
|
 |
|
  G.-X. Zhang, S. Kimura, K. Murao, K. Obata, H. Matsuyoshi, and M. Takaki Inhibition of cytochrome c release by 10-N-nonyl acridine orange, a cardiolipin-specific dye, during myocardial ischemia-reperfusion in the rat Am J Physiol Heart Circ Physiol, February 1, 2010; 298(2): H433 - H439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Park, Y.-T. Shen, V. Gaussin, G. R. Heyndrickx, J. Bartunek, R. R. G. Resuello, F. F. Natividad, R. N. Kitsis, D. E. Vatner, and S. F. Vatner Apoptosis predominates in nonmyocytes in heart failure Am J Physiol Heart Circ Physiol, August 1, 2009; 297(2): H785 - H791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Juric, C.-C. Chen, and L. F. Lau Fas-Mediated Apoptosis Is Regulated by the Extracellular Matrix Protein CCN1 (CYR61) In Vitro and In Vivo Mol. Cell. Biol., June 15, 2009; 29(12): 3266 - 3279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xiao, Q. She, Y. Wang, K. Luo, Y. Yin, R. Hu, and K. Huang Effect of allopurinol on cardiomyocyte apoptosis in rats after myocardial infarction Eur J Heart Fail, January 1, 2009; 11(1): 20 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-Q. Tan, J.-X. Wang, Z.-Q. Lin, Y.-R. Li, Y. Lin, and P.-F. Li Novel Cardiac Apoptotic Pathway: The Dephosphorylation of Apoptosis Repressor With Caspase Recruitment Domain by Calcineurin Circulation, November 25, 2008; 118(22): 2268 - 2276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ha, F. Hua, X. Liu, J. Ma, J. R. McMullen, T. Shioi, S. Izumo, J. Kelley, X. Gao, W. Browder, et al. Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism Cardiovasc Res, June 1, 2008; 78(3): 546 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Murphy and C. Steenbergen Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury Physiol Rev, April 1, 2008; 88(2): 581 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sanchis, M. Llovera, M. Ballester, and J. X. Comella An alternative view of apoptosis in heart development and disease Cardiovasc Res, February 1, 2008; 77(3): 448 - 451. [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Altemeier, X. Zhu, W. R. Berrington, J. M. Harlan, and W. C. Liles Fas (CD95) induces macrophage proinflammatory chemokine production via a MyD88-dependent, caspase-independent pathway J. Leukoc. Biol., September 1, 2007; 82(3): 721 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ihenetu, H. M. Qazzaz, F. Crespo, R. Fernandez-Botran, and R. Valdes Jr Digoxin-Like Immunoreactive Factors Induce Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Clin. Chem., July 1, 2007; 53(7): 1315 - 1322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Ibe, A. Saraste, S. Lindemann, S. Bruder, M. Buerke, H. Darius, K. Pulkki, and L.-M. Voipio-Pulkki Cardiomyocyte apoptosis is related to left ventricular dysfunction and remodelling in dilated cardiomyopathy, but is not affected by growth hormone treatment Eur J Heart Fail, February 1, 2007; 9(2): 160 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chao, Y. Shen, L. Li, H. Zhao, S. E. Meiler, S. A. Cook, and A. Rosenzweig Fas-associated death-domain protein inhibits TNF-{alpha} mediated NF-{kappa}B activation in cardiomyocytes Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2073 - H2080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gomez, N. Chavanis, L. Argaud, L. Chalabreysse, O. Gateau-Roesch, J. Ninet, and M. Ovize Fas-independent mitochondrial damage triggers cardiomyocyte death after ischemia-reperfusion Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2153 - H2158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. P.M. van Empel, A. T.A. Bertrand, L. Hofstra, H. J. Crijns, P. A. Doevendans, and L. J. De Windt Myocyte apoptosis in heart failure Cardiovasc Res, July 1, 2005; 67(1): 21 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Crow, K. Mani, Y.-J. Nam, and R. N. Kitsis The Mitochondrial Death Pathway and Cardiac Myocyte Apoptosis Circ. Res., November 12, 2004; 95(10): 957 - 970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Tao, E. Gao, N. S. Bryan, Y. Qu, H.-R. Liu, A. Hu, T. A. Christopher, B. L. Lopez, J. Yodoi, W. J. Koch, et al. Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: Role of S-nitrosation PNAS, August 3, 2004; 101(31): 11471 - 11476. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Salahudeen Cold ischemic injury of transplanted kidneys: new insights from experimental studies Am J Physiol Renal Physiol, August 1, 2004; 287(2): F181 - F187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Beranek, T. El-Sawy, and R. L. Fairchild Unusual Apoptosis in Experimental Cardiac Rejection Am. J. Pathol., December 1, 2003; 163(6): 2640 - 2642. [Full Text]
|
|
|
|
|
|
Y. Teshima, M. Akao, S. P. Jones, and E. Marban Cariporide (HOE642), a Selective Na+-H+ Exchange Inhibitor, Inhibits the Mitochondrial Death Pathway Circulation, November 4, 2003; 108(18): 2275 - 2281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bae, Y. Xiao, G. Li, C. A. Casiano, and L. Zhang Effect of maternal chronic hypoxic exposure during gestation on apoptosis in fetal rat heart Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H983 - H990. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Narula and H. W. Strauss P.S. I Love You: Implications of Phosphatidyl Serine (PS) Reversal in Acute Ischemic Syndromes J. Nucl. Med., March 1, 2003; 44(3): 397 - 399. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
