AJP - Heart Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 284: H528-H534, 2003. First published October 10, 2002; doi:10.1152/ajpheart.00752.2002
0363-6135/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/2/H528    most recent
00752.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (13)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fang, Q.
Right arrow Articles by Mayhan, W. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fang, Q.
Right arrow Articles by Mayhan, W. G.
Vol. 284, Issue 2, H528-H534, February 2003

Impairment of nitric oxide synthase-dependent dilatation of cerebral arterioles during infusion of nicotine

Qin Fang, Hong Sun, and William G. Mayhan

Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, Nebraska 68198-4575

The effects of nicotine on nitric oxide synthase (NOS)-dependent reactivity of cerebral arterioles remain uncertain. Our first goal was to examine whether infusion of nicotine alters NOS-dependent reactivity of cerebral arterioles. Our second goal was to examine the mechanisms that may account for the effects of nicotine on cerebral arterioles. We measured the diameter of pial arterioles to NOS-dependent (ADP and acetylcholine) and NOS-independent (nitroglycerin) agonists before and after the infusion of nicotine (2 µg · kg-1 · min-1 iv for 30 min, followed by a maintenance dose of 0.35 µg · kg-1 · min-1). ADP- and acetylcholine-induced vasodilatation was impaired after the infusion of nicotine. In contrast, nicotine did not alter vasodilatation to nitroglycerin. Next, we examined whether the impaired responses of pial arterioles during infusion of nicotine may be related to oxygen radicals. We found that application of superoxide dismutase or tetrahydrobiopterin during infusion of nicotine could prevent impaired NOS-dependent vasodilatation. Thus acute exposure of cerebral vessels to nicotine specifically impairs NOS-dependent dilatation via the production of oxygen radicals possibly related to an alteration in the utilization of tetrahydrobiopterin.

vasoreactivity; acetylcholine; ADP; nitroglycerin; oxygen radicals; tetrahydrobiopterin; superoxide dismutase


This article has been cited by other articles:


Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
H. Iida, M. Iida, M. Takenaka, N. Fukuoka, and S. Dohi
Rho-kinase inhibitor and Nicotinamide Adenine Dinucleotide PHosphate oxidase inhibitor prevent impairment of endothelium-dependent cerebral vasodilation by acute cigarette smoking in rats
Journal of Renin-Angiotensin-Aldosterone System, June 1, 2008; 9(2): 89 - 94.
[Abstract] [PDF]

Home page
 J. Appl. Physiol.Home page
D. M. Arrick and W. G. Mayhan
Acute infusion of nicotine impairs nNOS-dependent reactivity of cerebral arterioles via an increase in oxidative stress
J Appl Physiol, December 1, 2007; 103(6): 2062 - 2067.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. R. Nurkiewicz and M. A. Boegehold
High salt intake reduces endothelium-dependent dilation of mouse arterioles via superoxide anion generated from nitric oxide synthase
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1550 - R1556.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Q. Fang, H. Sun, D. M. Arrick, and W. G. Mayhan
Inhibition of NADPH oxidase improves impaired reactivity of pial arterioles during chronic exposure to nicotine
J Appl Physiol, February 1, 2006; 100(2): 631 - 636.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
S. P. Didion, C. M. Lynch, G. L. Baumbach, and F. M. Faraci
Impaired Endothelium-Dependent Responses and Enhanced Influence of Rho-Kinase in Cerebral Arterioles in Type II Diabetes
Stroke, February 1, 2005; 36(2): 342 - 347.
[Abstract] [Full Text] [PDF]

Home page
 Exp Biol MedHome page
E. R. Werner, A. C.F. Gorren, R. Heller, G. Werner-Felmayer, and B. Mayer
Tetrahydrobiopterin and Nitric Oxide: Mechanistic and Pharmacological Aspects
Exp Biol Med, December 1, 2003; 228(11): 1291 - 1302.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online