AJP - Heart Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 284: H598-H604, 2003. First published October 10, 2002; doi:10.1152/ajpheart.00687.2002
0363-6135/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/2/H598    most recent
00687.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Findlay, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Findlay, I.
Vol. 284, Issue 2, H598-H604, February 2003

Is there an A-type K+ current in guinea pig ventricular myocytes?

Ian Findlay

Faculté des Sciences, Centre National de la Recherche Scientifique UMR 6542, Université de Tours, 3200 Tours, France

A unique transient outward K+ current (Ito) has been described to result from the removal of extracellular Ca2+ from ventricular myocytes of the guinea pig (15). This study addressed the question of whether this current represented K+-selective Ito or the efflux of K+ via L-type Ca2+ channels. This outward current was inhibited by Cd2+, Ni2+, Co2+, and La3+ as well as by nifedipine. All of these compounds were equally effective inhibitors of the L-type Ca2+ current. The current was not inhibited by 4-aminopyridine. Apparent inhibition of the outward current by extracellular Ca2+ was shown to result from the displacement of the reversal potential of cation flux through L-type Ca2+ channels. The current was found not to be K+ selective but also permeant to Cs+. The voltage dependence of inactivation of the outward current was identical to that of the L-type Ca2+ current. It is concluded that extracellular Ca2+ does not mask an A-type K+ current in guinea pig ventricular myocytes.

transient outward current; L-type Ca2+ current; monovalent cation flux


This article has been cited by other articles:


Home page
 EuropaceHome page
E. H. Medei, J. H.M. Nascimento, R. C. Pedrosa, L. Barcellos, M. O. Masuda, S. Sicouri, M. V. Elizari, and A. C. Campos de Carvalho
Antibodies with beta-adrenergic activity from chronic chagasic patients modulate the QT interval and M cell action potential duration
Europace, July 1, 2008; 10(7): 868 - 876.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. Veeraraghavan and S. Poelzing
Mechanisms underlying increased right ventricular conduction sensitivity to flecainide challenge
Cardiovasc Res, March 1, 2008; 77(4): 749 - 756.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Dong, X. Sun, A. A. Prinz, and H.-S. Wang
Effect of simulated Ito on guinea pig and canine ventricular action potential morphology
Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H631 - H637.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
P. Zhabyeyev, T. Asai, S. Missan, and T. F. McDonald
Transient outward current carried by inwardly rectifying K+ channels in guinea pig ventricular myocytes dialyzed with low-K+ solution
Am J Physiol Cell Physiol, November 1, 2004; 287(5): C1396 - C1403.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
B. Rosati and D. McKinnon
Regulation of Ion Channel Expression
Circ. Res., April 16, 2004; 94(7): 874 - 883.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Zicha, I. Moss, B. Allen, A. Varro, J. Papp, R. Dumaine, C. Antzelevich, and S. Nattel
Molecular basis of species-specific expression of repolarizing K+ currents in the heart
Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1641 - H1649.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online