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Am J Physiol Heart Circ Physiol 284: H598-H604, 2003. First published October 10, 2002; doi:10.1152/ajpheart.00687.2002
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Vol. 284, Issue 2, H598-H604, February 2003

Is there an A-type K+ current in guinea pig ventricular myocytes?

Ian Findlay

Faculté des Sciences, Centre National de la Recherche Scientifique UMR 6542, Université de Tours, 3200 Tours, France

A unique transient outward K+ current (Ito) has been described to result from the removal of extracellular Ca2+ from ventricular myocytes of the guinea pig (15). This study addressed the question of whether this current represented K+-selective Ito or the efflux of K+ via L-type Ca2+ channels. This outward current was inhibited by Cd2+, Ni2+, Co2+, and La3+ as well as by nifedipine. All of these compounds were equally effective inhibitors of the L-type Ca2+ current. The current was not inhibited by 4-aminopyridine. Apparent inhibition of the outward current by extracellular Ca2+ was shown to result from the displacement of the reversal potential of cation flux through L-type Ca2+ channels. The current was found not to be K+ selective but also permeant to Cs+. The voltage dependence of inactivation of the outward current was identical to that of the L-type Ca2+ current. It is concluded that extracellular Ca2+ does not mask an A-type K+ current in guinea pig ventricular myocytes.

transient outward current; L-type Ca2+ current; monovalent cation flux


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