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Am J Physiol Heart Circ Physiol 284: H691-H697, 2003. First published October 31, 2002; doi:10.1152/ajpheart.00653.2002
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Vol. 284, Issue 2, H691-H697, February 2003

Echocardiographic measurement of cardiac output in rats

Michel Slama1, Dinko Susic2, Jasmina Varagic2, Jwari Ahn2, and Edward D. Frohlich2

1 Laboratoire de Pharmacologie et de Physiopathologie Cardiovasculaire, Faculté de Médecine, Université de Picardie Jules Vernes, 80054 Amiens, France; and 2 Research Division, Ochsner Clinic Foundation, New Orleans, Louisiana 70121

The systematic evaluation of different transthoracic echocardiographic (TTE) methods to determine cardiac output (CO) and the effect of changes in intravascular volume on echocardiographically determined indexes of cardiovascular structure in the rat has not been documented. With the use of 11 Wistar rats, simultaneous echocardiographic and thermodilution measurements of CO were compared at baseline and after blood withdrawal or transfusion at 43 different levels of intravascular volume and using 10 different echocardiographic approaches. The best correlation (r = 0.93; P < 0.0001), least bias (-3 ml/min), and best precision (16 ml/min) between thermodilution and echocardiographic methods were obtained at the level of aortic annulus using pulsed Doppler. In conclusion, CO could be accurately assessed in rats using TTE and pulsed Doppler at the level of the aortic annulus. This annulus was demonstrated to remain stable, but pulmonary annulus, thoracic aorta, mitral valve, and left ventricular diameters were found to be more modifiable during volumic changes.

Doppler; blood volume changes


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