AJP - Heart Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 284: H884-H891, 2003; doi:10.1152/ajpheart.00601.2002
0363-6135/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (5)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Seagard, J. L.
Right arrow Articles by Hopp, F. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seagard, J. L.
Right arrow Articles by Hopp, F. A.
Vol. 284, Issue 3, H884-H891, March 2003

Activity-dependent role of NMDA receptors in transmission of cardiac mechanoreceptor input to the NTS

J. L. Seagard, C. Dean, and F. A. Hopp

Zablocki Department of Veterans Affairs Medical Center and Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53295

Evidence suggests that transmission of barosensitive input from arterial baroreceptors and cardiac mechanoreceptors at nucleus tractus solitarius (NTS) neurons involves non-N-methyl-D-aspartate (NMDA) glutamate receptors, but there is a possibility that the contribution of NMDA receptors might increase during periods of increased afferent input, when enhanced neuronal depolarization could increase the activation of NMDA receptors by removal of a Mg2+ block. Thus the effects of NMDA on cardiac mechanoreceptor-modulated NTS neuronal discharges were examined at different levels of arterial pressure used to change cardiac mechanoreceptor afferent input. To determine whether the response was specific to NMDA, (±)-alpha -amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) was also administered at different levels of neuronal discharge. In anesthetized dogs, neuronal activity was recorded from the NTS while NMDA or AMPA was picoejected at high versus low arterial stimulating pressures. NMDA, but not AMPA, produced a significantly greater discharge of mechanoreceptor-driven NTS neurons at higher versus lower levels of stimulating pressure. These data suggest that the role played by NMDA receptors is greater during periods of enhanced neuronal depolarization, which could be produced by increases in afferent barosensitive input.

medulla; nucleus tractus solitarius; AMPA; baroreceptors


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
A. C. Bonham, C.-Y. Chen, S.-i. Sekizawa, and J. P. Joad
Plasticity in the nucleus tractus solitarius and its influence on lung and airway reflexes
J Appl Physiol, July 1, 2006; 101(1): 322 - 327.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. C. R. Dias and E. Colombari
Central nitric oxide modulates hindquarter vasodilation elicited by AMPA receptor stimulation in the NTS of conscious rats
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1330 - R1336.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C.-Y. Chen and A. C. Bonham
Glutamate suppresses GABA release via presynaptic metabotropic glutamate receptors at baroreceptor neurones in rats
J. Physiol., January 15, 2005; 562(2): 535 - 551.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. L. Seagard, C. Dean, S. Patel, D. J. Rademacher, F. A. Hopp, W. T. Schmeling, and C. J. Hillard
Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition
Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H992 - H1000.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online