AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 284: H1332-H1339, 2003. First published December 19, 2002; doi:10.1152/ajpheart.00715.2002
0363-6135/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/4/H1332    most recent
00715.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leite-Moreira, A. F.
Right arrow Articles by Rocha-Sousa, A. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leite-Moreira, A. F.
Right arrow Articles by Rocha-Sousa, A. A.
Vol. 284, Issue 4, H1332-H1339, April 2003

ET-1 increases distensibility of acutely loaded myocardium: a novel ETA and Na+/H+ exchanger-mediated effect

Adelino F. Leite-Moreira, Carmen Brás-Silva, Carla A. Pedrosa, and Amândio A. Rocha-Sousa

Department of Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal

This study investigated, in rabbit papillary muscles (n = 61) and human auricular strips (n = 7), effects of endothelin-1 (ET-1; 0.1-10 nM) on diastolic myocardial properties. ET-1 (1 nM) was also given in the presence of selective ETA or ETB antagonism, nonselective ETA/ETB antagonism, and Na+/H+ exchanger inhibition. Effects of 6.3 mM Ca2+ were also studied. ET-1 dose dependently increased inotropism. In contrast to baseline, in the presence of ET-1, resting tension (RT) decreased, after an isometric twitch, 3.4 ± 1.4, 6.9 ± 1.5, and 12.5 ± 3.1% with 0.1, 1, and 10 nM, respectively, reflecting an increase in myocardial distensibility. ET-1 effects were abolished with selective ETA as well as with nonselective ETA/ETB antagonism, whereas they were still present with ETB antagonism. Na+/H+ exchanger inhibition abolished ET-1 effects on distensibility, whereas it only partially inhibited positive inotropic effect. Ca2+ increased inotropism to a similar extent to ET-1 (1 nM) but did not affect distensibility. ET-1 therefore increased diastolic distensibility of acutely loaded human and nonhuman myocardium. This effect is mediated by ETA receptors, requires Na+/H+ exchanger activation, and cannot be elicited by Ca2+.

diastolic function; endothelin-1 receptors; cardiac overload; neurohormones; sodium-hydrogen exchanger


This article has been cited by other articles:


Home page
 Exp PhysiolHome page
P. Castro-Chaves, R. Fontes-Carvalho, M. Pintalhao, P. Pimentel-Nunes, and A. F. Leite-Moreira
Angiotensin II-induced increase in myocardial distensibility and its modulation by the endocardial endothelium in the rabbit heart
Exp Physiol, June 1, 2009; 94(6): 665 - 674.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. Kruger, S. Kotter, A. Grutzner, P. Lang, C. Andresen, M. M. Redfield, E. Butt, C. G. dos Remedios, and W. A. Linke
Protein Kinase G Modulates Human Myocardial Passive Stiffness by Phosphorylation of the Titin Springs
Circ. Res., January 2, 2009; 104(1): 87 - 94.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
W. J. Paulus, C. Tschope, J. E. Sanderson, C. Rusconi, F. A. Flachskampf, F. E. Rademakers, P. Marino, O. A. Smiseth, G. De Keulenaer, A. F. Leite-Moreira, et al.
How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology
Eur. Heart J., October 2, 2007; 28(20): 2539 - 2550.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
C. Bras-Silva and A. F. Leite-Moreira
Obligatory role of the endocardial endothelium in the increase of myocardial distensibility induced by endothelin-1.
Experimental Biology and Medicine, June 1, 2006; 231(6): 876 - 881.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
C. Bras-Silva, A. P. Fontes-Sousa, C. Moura, J. C. Areias, and A. F. Leite-Moreira
Impaired Response to ETB Receptor Stimulation in Heart Failure: Functional Evidence of Endocardial Endothelial Dysfunction?
Experimental Biology and Medicine, June 1, 2006; 231(6): 893 - 898.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
A. F Leite-Moreira
Current perspectives in diastolic dysfunction and diastolic heart failure.
Heart, May 1, 2006; 92(5): 712 - 718.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
B. C.W. Groenendijk, B. P. Hierck, J. Vrolijk, M. Baiker, M. J.B.M. Pourquie, A. C. Gittenberger-de Groot, and R. E. Poelmann
Changes in Shear Stress-Related Gene Expression After Experimentally Altered Venous Return in the Chicken Embryo
Circ. Res., June 24, 2005; 96(12): 1291 - 1298.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. F. Leite-Moreira and C. Bras-Silva
Inotropic effects of ETB receptor stimulation and their modulation by endocardial endothelium, NO, and prostaglandins
Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1194 - H1199.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online