AJP - Heart AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 284: H1358-H1368, 2003. First published December 12, 2002; doi:10.1152/ajpheart.00175.2002
0363-6135/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/4/H1358    most recent
00175.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wang, J.-J.
Right arrow Articles by Tyberg, J. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, J.-J.
Right arrow Articles by Tyberg, J. V.
Vol. 284, Issue 4, H1358-H1368, April 2003

Time-domain representation of ventricular-arterial coupling as a windkessel and wave system

Jiun-Jr Wang1, Aoife B. O'Brien4, Nigel G. Shrive2, Kim H. Parker3, and John V. Tyberg1

Departments of 1 Medicine and Physiology/Biophysics and 2 Civil Engineering, University of Calgary, Calgary, Alberta, Canada T2N 4N1; 3 Physiological Flow Studies Group, Department of Bioengineering, Imperial College of Science, Technology, and Medicine, London SW7 2AZ, United Kingdom; and 4 National University of Ireland, National Centre for Biomedical Engineering Science, Galway, Ireland

The differences in shape between central aortic pressure (PAo) and flow waveforms have never been explained satisfactorily in that the assumed explanation (substantial reflected waves during diastole) remains controversial. As an alternative to the widely accepted frequency-domain model of arterial hemodynamics, we propose a functional, time-domain, arterial model that combines a blood conducting system and a reservoir (i.e., Frank's hydraulic integrator, the windkessel). In 15 anesthetized dogs, we measured PAo, flows, and dimensions and calculated windkessel pressure (PWk) and volume (VWk). We found that PWk is proportional to thoracic aortic volume and that the volume of the thoracic aorta comprises 45.1 ± 2.0% (mean ± SE) of the total VWk. When we subtracted PWk from PAo, we found that the difference (excess pressure) was proportional to aortic flow, thus resolving the differences between PAo and flow waveforms and implying that reflected waves were minimal. We suggest that PAo is the instantaneous summation of a time-varying reservoir pressure (i.e., PWk) and the effects of (primarily) forward-traveling waves in this animal model.

aortic pressure; aortic flow; compliance; left ventricular ejection; waves


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. Kolyva, G. M. Pantalos, G. A. Giridharan, J. R. Pepper, and A. W. Khir
Discerning aortic waves during intra-aortic balloon pumping and their relation to benefits of counterpulsation in humans
J Appl Physiol, November 1, 2009; 107(5): 1497 - 1503.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
C J Ferro, C D Chue, R P Steeds, and J N Townend
Is lowering phosphate exposure the key to preventing arterial stiffening with age?
Heart, November 1, 2009; 95(21): 1770 - 1772.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
J. E. Sharman, J. E. Davies, C. Jenkins, and T. H. Marwick
Augmentation Index, Left Ventricular Contractility, and Wave Reflection
Hypertension, November 1, 2009; 54(5): 1099 - 1105.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
J Davies, K H Parker, D P Francis, A D Hughes, and J Mayet

Heart, June 1, 2009; 95(11): 937 - 938.
[Full Text] [PDF]

Home page
 HeartHome page
J. E Davies, K. H Parker, D. P Francis, A. D Hughes, and J. Mayet
What is the role of the aorta in directing coronary blood flow?
Heart, December 1, 2008; 94(12): 1545 - 1547.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Kolyva, J. A. E. Spaan, J. J. Piek, and M. Siebes
Windkesselness of coronary arteries hampers assessment of human coronary wave speed by single-point technique
Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H482 - H490.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J.-J. Wang, N. G. Shrive, K. H. Parker, and J. V. Tyberg
Effects of vasoconstriction and vasodilatation on LV and segmental circulatory energetics
Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1216 - H1225.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
S. M. Farasat, C. H. Morrell, A. Scuteri, C.-T. Ting, F. C.P. Yin, H. A. Spurgeon, C.-H. Chen, E. G. Lakatta, and S. S. Najjar
Pulse Pressure Is Inversely Related to Aortic Root Diameter Implications for the Pathogenesis of Systolic Hypertension
Hypertension, February 1, 2008; 51(2): 196 - 202.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. A. Flewitt, T. N. Hobson, J. Wang Jr., C. R. Johnston, N. G. Shrive, I. Belenkie, K. H. Parker, and J. V. Tyberg
Wave intensity analysis of left ventricular filling: application of windkessel theory
Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2817 - H2823.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J.-J. Wang, J. A. Flewitt, N. G. Shrive, K. H. Parker, and J. V. Tyberg
Systemic venous circulation. Waves propagating on a windkessel: relation of arterial and venous windkessels to systemic vascular resistance
Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H154 - H162.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online