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Am J Physiol Heart Circ Physiol 284: H1904-H1908, 2003. First published January 30, 2003; doi:10.1152/ajpheart.01150.2002
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Vol. 284, Issue 6, H1904-H1908, June 2003

SPECIAL TOPICS
Regulation of Cardiovascular Signaling by Kinins and Products of Similar Converting Enzyme Systems
Decreased renal NO excretion and reduced glomerular tuft area in mice lacking the bradykinin B2 receptor

Joost P. Schanstra1, Johan Duchene1, Françoise Praddaude1, Patrick Bruneval2, Ivan Tack1, Jacques Chevalier2, Jean-Pierre Girolami1, and Jean-Loup Bascands1

1 Institut National de la Santé et de la Recherche Médicale U388, Institut Louis Bugnard, Centre Hospitalier Universitaire Rangueil, 31052 Toulouse; 2 Institut National de la Santé et de la Recherche Médicale U430, Hôpital Broussais, 75674 Paris Cedex 14, France

Bradykinin B2 receptor knockout mice (B2-/-) have been useful to study the role of bradykinin under pathological conditions. With the use of these mice, it was shown that bradykinin plays an important role in angiogenesis, heart failure, salt-induced hypertension, and kidney fibrosis. Data on the role of the bradykinin B2 receptor under physiological conditions using these mice are controversial and scarce, because these mice have no typical phenotype. For this reason, we have studied, under physiological conditions, renal hemodynamics as well as a number of morphometric glomerular parameters of B2-/- mice on a homogenized genetic background and on mice bred in a pathogen-free environment. Backcrossed B2-/- mice had normal blood pressure and normal apparent renal hemodynamics and morphology. However, reduced renal nitrite excretion and glomerular cGMP content were found, which was associated with a reduced glomerular capillary surface area. These differences had, however, no detectable effects on renal hemodynamics. These differences between B2-/- and wild-type mice might become important under pathological conditions as shown by a number of studies using these bradykinin B2 receptor knockout mice.

kidney; hemodynamics; nitric oxide; backcross; genetic background


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