| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Physiology and Biophysics, Federal University of Minas Gerais, 31270901 Minas Gerais, Brazil
The systemic and
regional hemodynamics effects of ANG-(1-7) were
examined in urethane-anesthetized rats. The blood flow distribution (kidneys, skin, mesentery, lungs, spleen, brain, muscle, and adrenals), cardiac output, and total peripheral resistance were investigated by
using fluorescent microspheres. Blood pressure and heart rate were
recorded from the brachial artery. ANG-(1-7) infusion
(110 fmol · min
1 · 10 min1 iv) significantly increased blood flow to the kidney
(5.10 ± 1.07 to 8.30 ± 0.97 ml · min1 · g1),
mesentery (0.73 ± 0.16 to 1.17 ± 0.49 ml · min1 · g1),
brain (1.32 ± 0.44 to 2.18 ± 0.85 ml · min1 · g1),
and skin (0.07 ± 0.02 to 0.18 ± 0.07 ml · min1 · g1)
and the vascular conductance in these organs.
ANG-(1-7) also produced a significant increase in
cardiac index (30%) and a decrease in total peripheral resistance
(2.90 ± 0.55 to 2.15 ± 0.28 mmHg · ml1 · min · 100 g). Blood flow to the spleen, muscle, lungs, and adrenals, as well as
the blood pressure and heart rate, were not altered by the
ANG-(1-7) infusion. The selective
ANG-(1-7) antagonist A-779 reduced the blood flow in
renal, cerebral, mesenteric, and cutaneous beds and blocked the
ANG-(1-7)-induced vasodilatation in the kidney,
mesentery, and skin, suggesting a significant role of endogenous
ANG-(1-7) in these territories. The effects of
ANG-(1-7) on the cerebral blood flow, cardiac index,
systolic volume, and total peripheral resistance were partially
attenuated by A-779. A high dose of ANG-(1-7) (11 pmol · min1 · 10 min1) caused an opposite effect of that produced by the
low dose. Our results show for the first time that
ANG-(1-7) has a previously unsuspected potent effect
in the blood flow distribution and systemic hemodynamics.
regional blood flow; fluorescent microspheres
This article has been cited by other articles:
|
|
 |
|
  B. Rentzsch, M. Todiras, R. Iliescu, E. Popova, L. A. Campos, M. L. Oliveira, O. C. Baltatu, R. A. Santos, and M. Bader Transgenic Angiotensin-Converting Enzyme 2 Overexpression in Vessels of SHRSP Rats Reduces Blood Pressure and Improves Endothelial Function Hypertension, November 1, 2008; 52(5): 967 - 973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Gauthier, D. X. Zhang, L. Cui, K. Nithipatikom, and W. B. Campbell Angiotensin II Relaxations of Bovine Adrenal Cortical Arteries: Role of Angiotensin II Metabolites and Endothelial Nitric Oxide Hypertension, July 1, 2008; 52(1): 150 - 155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Filho, A. J. Ferreira, S. H. S. Santos, S. R. S. Neves, E. R. Silva Camargos, L. K. Becker, H. A. Belchior, M. F. Dias-Peixoto, S. V. B. Pinheiro, and R. A. S. Santos Selective increase of angiotensin(1-7) and its receptor in hearts of spontaneously hypertensive rats subjected to physical training Exp Physiol, May 1, 2008; 93(5): 589 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. S. Santos, A. J. Ferreira, and A. C. Simoes e Silva Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis Exp Physiol, May 1, 2008; 93(5): 519 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Tikellis, K. Bialkowski, J. Pete, K. Sheehy, Q. Su, C. Johnston, M. E. Cooper, and M. C. Thomas ACE2 Deficiency Modifies Renoprotection Afforded by ACE Inhibition in Experimental Diabetes Diabetes, April 1, 2008; 57(4): 1018 - 1025. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Joyner, L. A. A. Neves, K. Stovall, C. M. Ferrario, and K. B. Brosnihan Angiotensin-(1-7) serves as an aquaretic by increasing water intake and diuresis in association with downregulation of aquaporin-1 during pregnancy in rats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R1073 - R1080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B.L. Carvalho, F. V. Duarte, R. Faria-Silva, B. Fauler, L. T. da Mata Machado, R. D. de Paula, M. J. Campagnole-Santos, and R. A.S. Santos Evidence for Mas-Mediated Bradykinin Potentiation by the Angiotensin-(1-7) Nonpeptide Mimic AVE 0991 in Normotensive Rats Hypertension, October 1, 2007; 50(4): 762 - 767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Heeneman, J. C. Sluimer, and M. J.A.P. Daemen Angiotensin-Converting Enzyme and Vascular Remodeling Circ. Res., August 31, 2007; 101(5): 441 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Q. Velez, A. M. Bland, J. M. Arthur, J. R. Raymond, and M. G. Janech Characterization of renin-angiotensin system enzyme activities in cultured mouse podocytes Am J Physiol Renal Physiol, July 1, 2007; 293(1): F398 - F407. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Botelho-Santos, W. O. Sampaio, T. L. Reudelhuber, M. Bader, M. J. Campagnole-Santos, and R. A. Souza dos Santos Expression of an angiotensin-(1-7)-producing fusion protein in rats induced marked changes in regional vascular resistance Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2485 - H2490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Keidar, M. Kaplan, and A. Gamliel-Lazarovich ACE2 of the heart: From angiotensin I to angiotensin (1-7) Cardiovasc Res, February 1, 2007; 73(3): 463 - 469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Grobe, A. P. Mecca, H. Mao, and M. J. Katovich Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2417 - H2423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A.S. Santos, C. H. Castro, E. Gava, S. V.B. Pinheiro, A. P. Almeida, R. D. de Paula, J. S. Cruz, A. S. Ramos, K. T. Rosa, M. C. Irigoyen, et al. Impairment of In Vitro and In Vivo Heart Function in Angiotensin-(1-7) Receptor Mas Knockout Mice Hypertension, May 1, 2006; 47(5): 996 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Gurzu, M. Costuleanu, S. M. Slatineanu, A. Ciobanu, and G. Petrescu Are Multiple Angiotensin Receptor Types Involved in Angiotensin (1-7) Actions on Isolated Rat Portal Vein? Journal of Renin-Angiotensin-Aldosterone System, June 1, 2005; 6(2): 90 - 95. [Abstract] [PDF]
|
|
|
|
|
|
S. V. B. Pinheiro, A. C. Simoes e Silva, W. O. Sampaio, R. D. de Paula, E. P. Mendes, E. D. Bontempo, J. B. Pesquero, T. Walther, N. Alenina, M. Bader, et al. Nonpeptide AVE 0991 Is an Angiotensin-(1-7) Receptor Mas Agonist in the Mouse Kidney Hypertension, October 1, 2004; 44(4): 490 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. S. Santos, A. J. Ferreira, A. P. Nadu, A. N. G. Braga, A. P. de Almeida, M. J. Campagnole-Santos, O. Baltatu, R. Iliescu, T. L. Reudelhuber, and M. Bader Expression of an angiotensin-(1-7)-producing fusion protein produces cardioprotective effects in rats Physiol Genomics, May 19, 2004; 17(3): 292 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Skidgel, F. Alhenc-Gelas, and W. B. Campbell Regulation of Cardiovascular Signaling by Kinins and Products of Similar Converting Enzyme Systems: Prologue: Kinins and related systems. New life for old discoveries Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H1886 - H1891. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
