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Am J Physiol Heart Circ Physiol 284: H2242-H2246, 2003. First published February 6, 2003; doi:10.1152/ajpheart.00646.2002
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Vol. 284, Issue 6, H2242-H2246, June 2003

Ventricular remodeling induced by retinoic acid supplementation in adult rats

Sergio Alberto Rupp de Paiva, Leonardo Antonio Mamede Zornoff, Marina Politi Okoshi, Katashi Okoshi, Luiz Shiguero Matsubara, Beatriz Bojikian Matsubara, Antonio Carlos Cicogna, and Alvaro Oscar Campana

Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, 18618-00 São Paulo, Brazil

Retinoic acid (RA) plays a role in regulating cardiac geometry and function throughout life. The aim of this study was to analyze the cardiac effects of RA in adult rats. Wistar rats were randomly allocated to a control group (n = 18) receiving standard rat chow and a group treated with RA (n = 14) receiving standard rat chow supplemented with RA for 90 days. All animals were evaluated by echocardiography, isolated papillary muscle function, and morphological studies. Whereas the RA-treated group developed an increase in both left ventricular (LV) mass and LV end-diastolic diameter, the ratio of LV wall thickness to LV end-diastolic diameter remained unchanged when compared with the control group. In the isolated papillary muscle preparation, RA treatment decreased the time to peak developed tension and increased the maximum velocity of isometric relengthening, indicating that systolic and diastolic function was improved. Although RA treatment produced an increase in myocyte cross-sectional area, the myocardial collagen volume fraction was similar to controls. Thus our study demonstrates that small physiological doses of RA induce ventricular remodeling resembling compensated volume-overload hypertrophy in rats.

hypertrophy; echocardiography; papillary muscle; collagen


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