AJP - Heart Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 284: H2247-H2254, 2003. First published January 30, 2003; doi:10.1152/ajpheart.00613.2002
0363-6135/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/6/H2247    most recent
00613.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kroeker, C. A. G.
Right arrow Articles by Tyberg, J. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kroeker, C. A. G.
Right arrow Articles by Tyberg, J. V.
Vol. 284, Issue 6, H2247-H2254, June 2003

Pericardium modulates left and right ventricular stroke volumes to compensate for sudden changes in atrial volume

Carol A. Gibbons Kroeker, Nigel G. Shrive, Israel Belenkie, and John V. Tyberg

University of Calgary, Calgary, Alberta, Canada T2N 4N1

The pericardium may modulate acute compensatory changes in stroke volumes seen with sudden changes in cardiac volume, but such a mechanism has never been clearly demonstrated. In eight open-chest dogs, we measured left and right ventricular pressures, diameters, stroke volumes, and pericardial pressures during rapid (~300 ms) systolic infusions or withdrawals of ~25 ml blood into and out of the left atrium and right atrium. Control beats, the infusion/withdrawal beat, and 4-10 subsequent beats were studied. With infusions, ipsilateral ventricular end-diastolic transmural pressure, diameter, and stroke volume increased. With the pericardium closed, there was a compensatory decrease in contralateral transmural pressure, diameter, and stroke volume, mediated by opposite changes in transmural end-diastolic pressures. The sum of the ipsilateral increase and contralateral decrease in stroke volume approximated the infused volume. Corresponding changes were seen with blood withdrawals. This direct ventricular interaction was diminished when pericardial pressure was <5 mmHg and absent when the pericardium was opened. Pericardial constraint appears essential for immediate biventricular compensatory responses to acute atrial volume changes.

ventricular interaction; cardiac output; orthostatic hypotension; transmural pressure


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Liu, W. Zhang, and G. S. Kassab
Effects of myocardial constraint on the passive mechanical behaviors of the coronary vessel wall
Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H514 - H523.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. T. A. Esch, J. M. Scott, M. J. Haykowsky, D. C. McKenzie, and D. E. R. Warburton
Diastolic ventricular interactions in endurance-trained athletes during orthostatic stress
Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H409 - H415.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. A. Gibbons Kroeker, S. Adeeb, J. V. Tyberg, and N. G. Shrive
A 2D FE model of the heart demonstrates the role of the pericardium in ventricular deformation
Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2229 - H2236.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. R. Mitchell, W. A. Whitelaw, R. Sas, E. R. Smith, J. V. Tyberg, and I. Belenkie
RV filling modulates LV function by direct ventricular interaction during mechanical ventilation
Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H549 - H557.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. A. Waters, A. W. Bowman, and S. J. Kovacs
MRI-determined left ventricular "crescent effect": a consequence of the slight deviation of contents of the pericardial sack from the constant-volume state
Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H848 - H853.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R.A. Bleasdale, M.S. Turner, C.E. Mumford, P. Steendijk, V. Paul, J.V. Tyberg, J.A. Morris-Thurgood, and M.P. Frenneaux
Left Ventricular Pacing Minimizes Diastolic Ventricular Interaction, Allowing Improved Preload-Dependent Systolic Performance
Circulation, October 19, 2004; 110(16): 2395 - 2400.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. W. Bowman and S. J. Kovacs
Assessment and consequences of the constant-volume attribute of the four-chambered heart
Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H2027 - H2033.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.