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Am J Physiol Heart Circ Physiol 284: H2263-H2268, 2003. First published January 23, 2003; doi:10.1152/ajpheart.00416.2002
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Vol. 284, Issue 6, H2263-H2268, June 2003

Tonin in rat heart with experimental hypertrophy

Júlio César Borges*,1, José Antônio Silva Jr.*,3, Maria Aparecida Gomes2, Eliane Sa Lopes Lomez1, Katia Moraes Leite1, Ronaldo Carvalho Araujo4, Michael Bader5, João Bosco Pesquero3, and Jorge Luiz Pesquero1

Departments of 1 Physiology and Biophysics and 2 Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, 31270 Minas Gerais; 3 Department of Biophysics, Federal University of Sao Paulo, 04023-062 Sao Paulo; 4 University of Mogi das Cruzes, 087890-911 Mogi das Cruzes, Brazil; and 5 Max-Delbruck Center for Molecular Medicine, 13092 Berlin, Germany

The present study was undertaken to determine tonin expression and activity in rat heart presenting isoproterenol-induced hypertrophy. Renin, angiotensin-converting enzyme (ACE), and angiotensinogen (AG) expression were also determined. Wistar rats were treated with isoproterenol for 7 days (5 mg · kg-1 · day-1 sc). For untreated animals, the levels of tonin-specific activity in the atrium were 2.6- and 5.5-fold higher than those of the left and right ventricle, respectively. After treatment, the levels of tonin-specific activity increased twofold in the atrium but did not change in the ventricles. Renin expression was not detectable in these structures, and ACE expression levels did not change with treatment. AG expression was detected in the left ventricle at very low levels compared with the atrium and increased significantly only in the hypertrophied atrium (1.8-fold). Tonin mRNA was not detected in the ventricle but was found at low levels in the atrium, which increased after isoproterenol treatment. Our results permit us to conclude that tonin may play a role in the process of heart hypertrophy in the rat.

angiotensin II; isoproterenol; growth myocardium; renin; angiotensinogen

* J. C. Borges and J. A. Silva Jr. contributed equally to this work.




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